Spots Global Cancer Trial Database for Comparative Effectiveness of Different Surgical Approaches for Giant Pituitary Adenomas
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Trial Identification
Brief Title: Comparative Effectiveness of Different Surgical Approaches for Giant Pituitary Adenomas
Official Title: Comparative Effectiveness of Different Surgical Approaches for Giant Pituitary Adenomas
Study ID: NCT05448690
Interventions
Study Description
Brief Summary: The surgical treatment strategy for giant invasive pituitary adenoma is one of the current hot spots in the field of clinical research on pituitary adenoma. A comprehensive literature search resulted in numerous previous studies to investigate the efficacy, advantages and disadvantages of different surgical options. A single approach (transnasal or craniotomy) is theoretically less invasive and has a shorter hospital stay for the patient, but may result in postoperative bleeding due to residual tumor and damage to the intracranial vessels adhering to the tumor. The advantage of the combined approach is that the tumor can be removed to the greatest extent possible. In addition, postoperative suprasellar hemorrhage can be prevented by careful hemostasis or intracranial drainage by the transcranial team if necessary. In this way, the risk of postoperative bleeding due to residual tumor can be significantly reduced. In some cases, waiting a few months after the initial surgery for a second-stage procedure may also be an option when the patient's condition does not allow for a combined access procedure, when the tumor is hard, or when the blood preparation is insufficient. However, staged surgery increases the financial burden on the patient, and local scar formation may make second-stage surgery more difficult and decrease the likelihood of endocrine remission of functional pituitary tumors. Given the complexity of the treatment of giant invasive pituitary adenoma, there is a need to conduct studies comparing the combined transnasal cranial approach, the single access transnasal or cranial approach, and the staged approach simultaneously to assess whether the combined transnasal cranial approach is superior to the single access transnasal or cranial approach or the staged approach in improving the tumor resection rate in giant invasive pituitary adenoma.
Detailed Description:
Keywords
Eligibility
Minimum Age: 6 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Chongqing People's Hospital, Chongqing, Chongqing, China
The first affliated hospital of Fujian Medical Hospital, Fuzhou, Fujian, China
The First Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
General hospital of Eastern Theater Command, Nanjing, Jiangsu, China
The First Affiliated Hospital of China Medical University, Shenyang, Jilin, China
General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China
The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, China
Huashan Hospital, Shanghai, Shanghai, China
Shanghai General Hospital, Shanghai, Shanghai, China
Shanghai Renji Hospital, Shanghai, Shanghai, China
Changzhi People's Hospital, Changzhi, Shanxi, China
The first hospital of Shanxi Medical University, Taiyuan, Shanxi, China
The first affliated hospital of Kunming Medical University, Kunming, Yunnan, China
Contact Details
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