Spots Global Cancer Trial Database for Effect of Menstrual Cycle on Traumatic Systemic Response

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Trial Identification

Brief Title: Effect of Menstrual Cycle on Traumatic Systemic Response

Official Title: ASSESSMENT OF SYSTEMIC RESPONSES TO TRAUMA IN DIFFERENT PHASES OF THE MENSTRUAL CYCLE: IN PATIENTS UNDERWENT MODIFIED RADICAL MASTECTOMY A Clinical Study

Study ID: NCT03283345

Conditions

Systemic Inflammatory Response Syndrome

Interventions

modified radical mastectomy

Study Description

Brief Summary: It is aimed to evaluate pathophysiology of systemic responses to trauma via using interleukin (IL) -1 and IL-6 levels and determining timing of surgery through phases of menstrual cycle.

Detailed Description: 89 female breast cancer patient who underwent modified radical mastectomy included into study. Menstrual history and hormone levels were used to determine menstrual phase: luteal, follicular, and other. IL-1β and IL-6 levels, which are related to severeness of inflammation, were measured one day before and one day after surgery. Those are statistically analysed to show effect of timing of breast surgery on responses to trauma in postmenopausal and premenopausal women during different phases of their menstrual cycles