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Brief Title: CD4-specific CAR T Cells (CD4 CAR T Cells) for Relapsed/Refractory T Cell Malignancies
Official Title: CD4-specific CAR T Cells (CD4 CAR T Cells) for Relapsed/Refractory T Cell Malignancies
Study ID: NCT04162340
Brief Summary: This is a phase I, interventional, single arm, open label, treatment study to evaluate the safety and tolerability of CD4 CAR T cells in patients with relapsed and/or refractory T cell lymphoma.
Detailed Description: CD4-specific CAR is a chimeric antigen receptor immunotherapy treatment designed to treat lymphoma/leukemia expressing CD4 antigen. CD4+ T cell lymphomas are a subset of leukemias and lymphomas that are positive for the surface protein CD4. The purpose of this study is to evaluate the efficacy and safety of CD4 CAR T cells.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
Chengdu Military General Hospital, Chengdu, Sichuan, China
Name: Hongyu Zhang, MD/PhD
Affiliation: Peking University Shenzhen Hospital, China
Role: PRINCIPAL_INVESTIGATOR
Name: Fang Liu, MD/PhD
Affiliation: Chengdu Military Hospital
Role: PRINCIPAL_INVESTIGATOR