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Brief Title: CT-Guided Adaptive Radiation Therapy Combine With Anti-PD-1 Antibody Adjuvant Immunotherapy for Thoracic Cancer Patients
Official Title: A Safety and Efficacy Study of CT-Guided Adaptive Radiation Therapy With Anti-PD-1 Antibody Adjuvant Immunotherapy in Patients With Thoracic Cancer (CARTAI)
Study ID: NCT03732430
Brief Summary: This phase II study is to evaluate the safety and efficacy of CT-based adaptive radiation therapy followed by adjuvant anti-PD-1 antibody immunotherapy in treating patients with different types and stages of thoracic malignancies. (CARTAI)
Detailed Description: PRIMARY OBJECTIVES: I. To evaluate the safety and toxicity of anti-programmed cell death 1 (PD-1) inhibition consolidation therapy after radiation therapy for multiple thoracic malignancies. SECONDARY OBJECTIVES: I. To assess the efficacy of adjuvant anti-PD-1 antibody immunotherapy after radiotherapy. II. To understand the dynamics and interactions of IDO with others immune pathway biomarkers. III. To evaluate whether IDO immune status could predict the treatment outcomes of radiation and immune combined therapy.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang, China
Name: Fengming (Spring) Kong, MD
Affiliation: Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
Role: PRINCIPAL_INVESTIGATOR
Name: Haihua Yang, MD
Affiliation: Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
Role: PRINCIPAL_INVESTIGATOR
Name: Yinnan Meng, MD
Affiliation: Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
Role: PRINCIPAL_INVESTIGATOR