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Brief Title: Extension Study of Bomedemstat (IMG-7289/MK-3543) in Participants With Myeloproliferative Neoplasms (IMG-7289-CTP-202/MK-3543-005)
Official Title: A Multi-Center, Open Label, Extension Study Evaluating the Safety and Efficacy of Bomedemstat for the Treatment of Patients With Myeloproliferative Neoplasms (MPNs) Enrolled in a Prior Bomedemstat Clinical Study
Study ID: NCT05223920
Brief Summary: This is a multi-center, open-label extension study to assess the long-term safety and efficacy of bomedemstat (MK-3543, formerly called IMG-7289) administered orally once daily in participants with an MPN who participated in a prior bomedemstat study such as, but not limited to, IMG-7289-CTP-102 and IMG-7289-CTP-201 (referred to hereafter as 'feeder studies').
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
University of Miami Leonard M. Miller, Miami, Florida, United States
University of Michigan, Ann Arbor, Michigan, United States
Cleveland Clinic Foundation, Cleveland, Ohio, United States
UMPC Hillman Cancer Center, Pittsburgh, Pennsylvania, United States
Fred Hutchinson Cancer Center, Seattle, Washington, United States
Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Royal North Shore Hospital, Saint Leonards, New South Wales, Australia
Gold Coast Hospital and Health Service, Southport, Queensland, Australia
Royal Adelaide Hospital, Adelaide, South Australia, Australia
Universittsklinikum Essen, Essen, , Germany
Queen Mary Hospital, Hong Kong, , Hong Kong
Ospedale di Circolo-a Fondazione Macchi, Varese, VA, Italy
Azienda Ospedaliera SS. Antonio, Alessandria, , Italy
Azienda Ospedaliero-Universitaria Careggi - S.O.D. Ematologia (CRIMM), Firenze, , Italy
Azienda Ospedaliero Universitaria di Bologna, Pavia, , Italy
Middlemore Clinical Trials, Papatoetoe, Aukland, New Zealand
Waitemata District Health Board, Takapuna, Aukland, New Zealand
University College London Hospitals NHS Foundation Trust, London, , United Kingdom
Guy's and Saint Thomas' NHS Foundation Trus, London, , United Kingdom
Name: Medical Director
Affiliation: Merck Sharp & Dohme LLC
Role: STUDY_DIRECTOR