Spots Global Cancer Trial Database for Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels

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Trial Identification

Brief Title: Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels

Official Title: Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels

Study ID: NCT01811199

Conditions

Thyroid Cancer

Breast Cancer

Interventions

Study Description

Brief Summary: Hypothesis: Dexamethasone reduces postoperative emesis in thyroidectomy and mastectomy patients.

Detailed Description: This study has been done to further study the effectiveness of dexamethasone in the prevention of postoperative emesis after breast and thyroid surgery and at the same time, the mechanism of action was investigated. In this prospective, randomized controlled trial it was hypothesized that corticosteroids exert their antiemetic effects in postoperative period via plasma prostaglandin F2 alpha (PGF2 α) and plasma leukotriene C4 (LTC4) inhibition.