Spots Global Cancer Trial Database for Dental Safety Profile of High-Dose Radioiodine Therapy
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Trial Identification
Brief Title: Dental Safety Profile of High-Dose Radioiodine Therapy
Official Title: The Dental Safety Profile of High-Dose Radioiodine Therapy for Thyroid Cancer
Study ID: NCT00439478
Conditions
Interventions
Study Description
Brief Summary: We aim to assess the incidence of oral and dental adverse events after high-dose radioiodine therapy for differentiated thyroid cancer.
Detailed Description: Sialadenitis and xerostomia are the most frequent adverse events of high-dose radioiodine therapy. Saliva has vital functions in maintaining periodontal and oral health. Therefore, xerostomia not only impairs quality of life permanently, but may also increase the risk of caries and tooth extractions. Nevertheless, despite more than 6 decades of radioiodine therapy for thyroid cancer, large studies on long-term oral adverse events are still lacking. In the present study, we investigate the influence of high-dose radioiodine therapy on the long-term oral health.
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University Hospital, Basel, , Switzerland
Contact Details
Name: Beat Müller, MD
Affiliation: Division of Endocrinology, University Hospital Basel
Role: STUDY_DIRECTOR
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