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Brief Title: An Open-label, Multicenter, Phase II Study of Dovitinib in Advanced Thyroid Cancer
Official Title:
Study ID: NCT01964144
Brief Summary: There has been no effective treatment for advanced thyroid cancer that is not amenable to surgery and that does not concentrate iodine. Response rates with chemotherapy have been so low that best supportive care has been the standard of care for most patients. In recent phase I and phase II clinical studies, dovitinib has shown activity as a single agent in solid tumors. Therefore, we will conduct a phase II, single-arm trial to determine the efficacy of dovitinib in radioactive iodine-refractory recurrent or metastatic thyroid cancer.
Detailed Description:
Minimum Age: 20 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, , Korea, Republic of