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Spots Global Cancer Trial Database for Molecular Markers in Thyroid Cancer

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Molecular Markers in Thyroid Cancer

Official Title: Molecular Markers in the Diagnostic and Prognostic Evaluation of Thyroid Cancer

Study ID: NCT00598364

Conditions

Thyroid Cancer

Interventions

Study Description

Brief Summary: The purpose of this study is to evaluate how common gene mutations are in benign and malignant thyroid lesions.

Detailed Description: The overall objective of this study is to evaluate the prevalence of molecular markers in patients with benign and malignant thyroid lesions. This study consists of: Retrospective review of archived surgical pathology specimens at Oregon Health \& Science University (OHSU) from patients with thyroid cancer or benign thyroid disease (nodules or goiter) who underwent thyroidectomy and/or neck dissection as standard of care. Molecular markers will be evaluated on archived tissue. Molecular markers will be correlated with clinical information extracted from OHSU medical records: histologic subtype of cancer, measures of tumor aggressiveness (capsular and angiolymphatic invasion, local invasion, lymph node and distant metastases, TNM stage(TNM Classification of Malignant Tumours)) and clinical outcome (recurrence, distant metastases and death). Patients with other malignancies presenting for standard of care services will have peripheral blood collected for DNA, RNA and buffy coat/white blood cells as a "positive" control for the DNA/RNA isolation techniques and mutation assays, as other cancers commonly express some of the same mutations. Normals will have peripheral blood collected for DNA, RNA and buffy coat/white blood cells as a "negative" control for the DNA/RNA isolation techniques and mutation assays.

Eligibility

Minimum Age: 1 Year

Eligible Ages: CHILD, ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Oregon Health & Science University, Portland, Oregon, United States

Contact Details

Name: Kathryn G. Schuff, M.D.

Affiliation: Oregon Health and Science University

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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