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Spots Global Cancer Trial Database for Recombinant Thyrotropin PET-CT Fusion Scanning in Thyroid Cancer

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Trial Identification

Brief Title: Recombinant Thyrotropin PET-CT Fusion Scanning in Thyroid Cancer

Official Title: Utility of Recombinant Human Thyrotropin (rTSH) PET-CT Fusion Scanning to Identify Residual Well-differentiated Epithelial Thyroid Cancer

Study ID: NCT00181168

Conditions

Thyroid Cancer

Interventions

Euthyroid Group

Study Description

Brief Summary: The purpose of this study is to determine \[for patients with previously treated well-differentiated thyroid cancer and evidence of residual disease based on serum thyroglobulin (Tg) level\] whether positron emission tomography-computed tomography (PET-CT) fusion scanning performed after recombinant thyroid-stimulating hormone (TSH) (rTSH, thyrotropin alfa for injection) will be more sensitive for the detection of disease sites than PET-CT scanning without rTSH. The study will also determine if this information will significantly alter the therapeutic approach in some patients.

Detailed Description: PET/CT was performed before (basal PET) and 24 - 48 h after rhTSH administration (rhTSH-PET) in 63 patients (52 papillary and 11 follicular thyroid cancers). Images were blindly analyzed by two readers. The proposed treatment plan was prospectively assessed before basal PET, after basal PET, and again after rhTSH-PET.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Johns Hopkins Division of Endocrinology & Metabolism, Baltimore, Maryland, United States

M.D. Anderson Cancer Center, Houston, Texas, United States

Institute Gustave Roussy, Paris, , France

Contact Details

Name: Paul W Ladenson, MD

Affiliation: Johns Hopkins University

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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