Spots Global Cancer Trial Database for Molecular Profile of Thyroid Nodules

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Trial Identification

Brief Title: Molecular Profile of Thyroid Nodules

Official Title: Study of Molecular-genetic Profile of Thyroid Nodules

Study ID: NCT05323669

Conditions

Thyroid Cancer

Thyroid Nodule

Interventions

Molecular testing

Study Description

Brief Summary: Profiling and comparative analysis of genomic alterations and miRNA expression in benign and malignant thyroid tumors using histological and cytological specimens will be performed. Obtained information is necessary to create a molecular test to refine the cancer risk of cytologically indeterminate thyroid nodules.

Detailed Description: This is an non-randomised retrospective study consisting of 2 parts. Part A. Histological specimens (formalin fixed paraffin embedded) of patients who were operated on for benign and malignant thyroid disorders will undergo molecular testing to create a molecular profile of thyroid nodules characteristic of Belarusian population. Part B. Fixed cytological smears of indeterminate thyroid nodules (categories III, IV and V according to Bethesda scoring system) of operated patients will undergo molecular testing to evaluate the possibility and reliability of molecular testing of fixed cytological smears using available assays.