⭐️⭐️⭐️⭐️⭐️ "A total no brainer"

⭐️⭐️⭐️⭐️⭐️ "Love this, so easy."

Spots is the easy way to track your skin, mole and cancer changes.

Spots Global Cancer Trial Database for Zileuton With or Without Celecoxib As Chemopreventive Agents in Smokers

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Zileuton With or Without Celecoxib As Chemopreventive Agents in Smokers

Official Title: Modulation of Arachidonic Acid Metabolism by Chemopreventive Agents in Smokers

Study ID: NCT01021215

Study Description

Brief Summary: The goal of this clinical research study is to learn how zileuton alone or the combination of zileuton and celecoxib may affect certain chemicals in the body that may be linked with a risk for smoking-related lung disease. These effects will be measured by a urine test

Detailed Description: PRIMARY OBJECTIVES: I. To determine whether short-term administration of zileuton, a 5-lipoxygenase (5-LO) inhibitor, in current smokers will suppress the formation of urinary leukotriene E4 (LTE4) and shunt arachidonic acid into the cyclooxygenase (COX) pathway, resulting in elevated urinary prostaglandin E-metabolite (PGE-M). SECONDARY OBJECTIVES: I. To determine whether short-term co-administration of celecoxib, a selective COX-2 inhibitor, and zileuton suppresses levels of both urinary LTE4 and PGE-M in current smokers. II. To evaluate the association between baseline levels of urinary LTE4 and magnitude of the arachidonic acid shunt induced by zileuton. OUTLINE: Patients are randomized to 1 of 2 treatment arms. ARM I: Patients receive zileuton orally (PO) twice daily (BID) on days 1-6. ARM II: Patients receive zileuton as in Arm I and celecoxib PO BID on days 1-6.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Weill Cornell Medical College in New York City, Cornell University, New York, New York, United States

MD Anderson Cancer Center - Consortium Lead Organzation, Houston, Texas, United States

Contact Details

Name: Powel Brown, MD

Affiliation: University of Texas (UT) MD Anderson Cancer Center

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

Logo

Take Control of Your Skin and Body Changes Today.

Try out Spots for free, set up only takes 2 mins.

spots app storespots app store

Join others from around the world: