Spots Global Cancer Trial Database for Multimodal Connectome Study of Brain Tumor-operated Patients

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Trial Identification

Brief Title: Multimodal Connectome Study of Brain Tumor-operated Patients

Official Title: Multimodal Connectome Study of Brain Tumor-operated Patients

Study ID: NCT04163315

Conditions

Tumor, Brain

Interventions

dMRI, fMRI and electrocorticography

Study Description

Brief Summary: In this pilot study, the investigators propose a multimodal evaluation of the brain connectivity of brain tumor patients, in order to better understand the effects induced by focal lesions on brain structure and function, as well as brain plasticity mechanisms that may occur in such condition. The investigators aim at drawing a multimodal brain connectivity map of focally brain-damaged patients, with a view to improve onco-functional neurosurgical practices.

Detailed Description: Patients included in the present study will first perform the pre-operative MRI (dMRI and fMRI) with a specific High Resolution Angular Diffusion (HARDI) sequence and a functional acquisition at rest. Then, the investigators will record their cortico-cortical evoked potentials elicited by direct electrostimulation during the surgery, just before the tumor removal, following our usual protocol. Finally, all data (clinical, diffusion, electrical and functional connectivity) will be processed and correlated to each other.