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Spots Global Cancer Trial Database for A Study Investigating agenT-797 in Participants With Relapsed/Refractory Solid Tumors

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Trial Identification

Brief Title: A Study Investigating agenT-797 in Participants With Relapsed/Refractory Solid Tumors

Official Title: A Phase 1, Open-Label Study of the Safety, Tolerability and Preliminary Clinical Activity of Allogeneic Invariant Natural Killer T (iNKT) Cells (agenT-797) as a Single Agent and in Combination With Approved Immune Checkpoint Inhibitors in Patients With Relapsed/ Refractory Solid Tumors

Study ID: NCT05108623

Conditions

Tumor, Solid

Study Description

Brief Summary: This is a Phase 1, open-label study to explore the safety, tolerability, and preliminary clinical activity of agenT-797, an unmodified, allogeneic iNKT cell therapy, in participants with relapsed/refractory (r/r) solid tumors, as well as define the recommended phase II dose in solid tumors. This Phase 1 study will also explore the safety, tolerability, and preliminary clinical activity of agenT-797 in combination with approved immune checkpoint inhibitors (ICIs), including pembrolizumab and nivolumab, in participants with r/r solid tumors.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University of Southern California, Los Angeles, California, United States

University of Colorado, Aurora, Colorado, United States

Norton Cancer Health, Louisville, Kentucky, United States

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

University of Cincinnati Cancer Center, Cincinnati, Ohio, United States

Providence Portland Medical Center, Portland, Oregon, United States

LifeSpan - Rhode Island Hospital, Providence, Rhode Island, United States

Sarah Cannon Research Institute, Nashville, Tennessee, United States

Contact Details

Name: Medical Director

Affiliation: MiNK Therapeutics

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

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