Spots Global Cancer Trial Database for Clinical Study on the Re-irradiation of Lateral Pelvic Recurrences of Gynecological Malignancies

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Trial Identification

Brief Title: Clinical Study on the Re-irradiation of Lateral Pelvic Recurrences of Gynecological Malignancies

Official Title: Phase II Clinical Study on the Re-irradiation of Lateral Pelvic Recurrences of Gynecological Malignancies

Study ID: NCT05457595

Conditions

Tumor Recurrence

Malignant Epithelial Neoplasm of Vulva

Malignant Epithelial Tumor of Ovary

Malignant Epithelial Neoplasm

Interventions

carbon ion radiation therapy

Study Description

Brief Summary: The study aims to obtain a local control rate in patients with lateral pelvic relapses of gynecologycal cancers previously irradiated. High LET (Linear Energy Transfer) particles as carbon ions can guarantee a biologic advantage compared to photons in radioresistant neoplasms, given to their higher biological efficacy (RBE).

Detailed Description: Primary aim: estimate the effect, in terms of clinical response, of carbon ion treatment (CIRT) in patients with lateral pelvic recurrences of gynecological malignancies. Secondary aims: 1. To describe the safety profile of carbon ion therapy. 2. To estimate the effect, in terms of survival, of carbon ion treatment