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Spots Global Cancer Trial Database for A Phase I Study of PLX038 in Patients With Advanced Solid Tumors

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Trial Identification

Brief Title: A Phase I Study of PLX038 in Patients With Advanced Solid Tumors

Official Title: A Phase I Study of PLX038 in Patients With Advanced Solid Tumors

Study ID: NCT02646852

Interventions

PLX038

Study Description

Brief Summary: This is a Phase I, open-label, two-arm, dose escalation study of PLX038 intravenous infusion administered to patients with refractory or relapsed solid tumors. This study will explore two different dosing schedules: Arm 1, once every 3 week (q3w), and Arm 2, once weekly for 2 consecutive weeks of a 4-week cycle.

Detailed Description: PLX038 is an investigational drug product that has demonstrated reasonable antitumor activity in preclinical colorectal, gastric and lung tumor models in animals. This is a first in human trial to determine the maximum, safest dose of PLX038 IV that can be administered to patients either once every 3 weeks or once every 2 weeks.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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