Spots Global Cancer Trial Database for Chromoendoscopy for Ulcerative Colitis Surveillance

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Trial Identification

Brief Title: Chromoendoscopy for Ulcerative Colitis Surveillance

Official Title: Impact of Chromoendoscopy on the Detection of Neoplasia in Ulcerative Colitis

Study ID: NCT00274209

Conditions

Ulcerative Colitis

Crohn's Disease

Interventions

Chromoendoscopy with magnification

Study Description

Brief Summary: Long-standing ulcerative colitis is associated with an increased cancer risk. Chromoendoscopy with dye spraying can detect subtle abnormalities that are not visible with standard endoscopy. The purpose of this study is to determine if chromoendoscopy with fewer "targeted biopsies" can replace standard colonoscopy with multiple "random" biopsies.

Detailed Description: Patients with ulcerative colitis (UC) are at increased risk for colon cancer. Current guidelines recommend periodic surveillance colonoscopy in individuals who fulfill certain high-risk criteria. Endoscopists must perform a high number of biopsies (over 33 per patient) in order to increase the yield of such procedures. Chromoendoscopy (CE) has the ability to identify subtle lesions that are otherwise missed by standard endoscopy. Whether CE can replace standard colonoscopy in the surveillance of patients with UC is unknown. Comparison: both standard biopsies and targeted biopsies will be obtained during colonoscopy from patients with UC who are candidates for surveillance colonoscopy. The yield of the two methods will be compared based on the number of biopsies required to identify one dysplastic (precancerous) lesion.