Spots Global Cancer Trial Database for Skeletal Muscle Energy Metabolism in Undernourished Patients With Gastrointestinal Cancer
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Trial Identification
Brief Title: Skeletal Muscle Energy Metabolism in Undernourished Patients With Gastrointestinal Cancer
Official Title: Study of Alterations in Skeletal Muscle Energy Metabolism in Undernourished Patients With Gastrointestinal Cancer
Study ID: NCT02573974
Interventions
Study Description
Brief Summary: Undernutrition associated with cancer, or cancer cachexia results from a deterioration of the energy balance that leads to a gradual mobilization of energy reserves in the body and to increasing deterioration of the nutritional status of patients. This will thus significantly reduce quality of life and survival of patients with a lower tolerance to cancer treatments. Despite undeniable progress in knowledge, many pathophysiological mechanisms remain few or not explored, which could explain that there is still no satisfactory therapeutic solution to halt the gradual deterioration of the nutritional status of patients. In this sense, apart from preclinical data obtained in animal models, there is currently no clinical study on the functioning of skeletal muscle energy metabolism in undernourished patients suffering of cancer.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Service d'Hépato-gastroentérologie et de Cancérologie Digestive, CHRU de TOURS, Tours, , France
Contact Details
Name: Thierry LECOMTE, MD-PhD
Affiliation: University Hospital, Tours
Role: PRINCIPAL_INVESTIGATOR
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