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Brief Title: Donafenib and Toripalimab Combined With TACE in Patients With Unresectable Hepatocellular Carcinoma
Official Title: Dose Escalation Study Of Donafenib and Toripalimab Combined With TACE in Patients With Unresectable Hepatocellular Carcinoma
Study ID: NCT04605185
Brief Summary: This study is the single-center, open-label phase I clinical trial to evaluate tolerability, safety and efficacy of Donafenib and JS001 in combination with TCAE in patients with Unresectable Hepatocellular Carcinoma.
Detailed Description: The phase I clinical trial is to determine the maximum tolerated dose (MTD) and dose limiting toxicity (DLT) of Donafenib in this regimen, and select an acceptable safe dose for the phase II clinical trial(RP2D).
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Hunan Cancer Hospital, Changsha, Hunan, China
Name: Shanzhi Gu, MD
Affiliation: Hunan Cancer Hospital
Role: PRINCIPAL_INVESTIGATOR