Spots Global Cancer Trial Database for MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma
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Trial Identification
Brief Title: MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma
Official Title: A Phase III, Randomized, Open-Label, Multicenter, Global Study of Volrustomig (MEDI5752) in Combination With Carboplatin Plus Pemetrexed Versus Platinum Plus Pemetrexed or Nivolumab Plus Ipilimumab in Participants With Unresectable Pleural Mesothelioma (eVOLVE-Meso)
Study ID: NCT06097728
Conditions
Study Description
Brief Summary: This is a phase III, randomized, open-label, multicenter, global study to determine the efficacy and safety of Volrustomig (MEDI5752) + Carboplatin + Pemetrexed vs the investigator's choice of platinum + Pemetrexed or Nivolumab + Ipilimumab in participants with unresectable pleural mesothelioma.
Detailed Description: Adult patients with histologically proven diagnosis of pleural mesothelioma with advanced unresectable disease are eligible to be enrolled. Patients will be randomized 1:1 to receive Volrustomig (MEDI5752) + Carboplatin + Pemetrexed or the investigator's choice of platinum+Pemetrexed or Nivolumab+Ipilimumab, based on their histology.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Research Site, Phoenix, Arizona, United States
Research Site, Duarte, California, United States
Research Site, Santa Rosa, California, United States
Research Site, Aurora, Colorado, United States
Research Site, Jacksonville, Florida, United States
Research Site, Atlanta, Georgia, United States
Research Site, Chicago, Illinois, United States
Research Site, Rochester, Minnesota, United States
Research Site, Saint Louis, Missouri, United States
Research Site, East Brunswick, New Jersey, United States
Research Site, Commack, New York, United States
Research Site, Cleveland, Ohio, United States
Research Site, Columbus, Ohio, United States
Research Site, Portland, Oregon, United States
Research Site, Portland, Oregon, United States
Research Site, Philadelphia, Pennsylvania, United States
Research Site, Houston, Texas, United States
Research Site, Fairfax, Virginia, United States
Research Site, Chermside, , Australia
Research Site, Clayton, , Australia
Research Site, Melbourne, , Australia
Research Site, Nedlands, , Australia
Research Site, Anderlecht, , Belgium
Research Site, Antwerpen, , Belgium
Research Site, Gent, , Belgium
Research Site, Hasselt, , Belgium
Research Site, Leuven, , Belgium
Research Site, Sint-Niklaas, , Belgium
Research Site, Barretos, , Brazil
Research Site, Fortaleza, , Brazil
Research Site, Joao Pessoa, , Brazil
Research Site, Porto Alegre, , Brazil
Research Site, Rio de Janeiro, , Brazil
Research Site, Santo Andre, , Brazil
Research Site, São Paulo, , Brazil
Research Site, Edmonton, Alberta, Canada
Research Site, London, Ontario, Canada
Research Site, Ottawa, Ontario, Canada
Research Site, Toronto, Ontario, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Quebec, , Canada
Research Site, Beijing, , China
Research Site, Beijing, , China
Research Site, Changsha, , China
Research Site, Chengdu, , China
Research Site, Guangzhou, , China
Research Site, Guangzhou, , China
Research Site, Hangzhou, , China
Research Site, Harbin, , China
Research Site, Kunming, , China
Research Site, Lanzhou, , China
Research Site, Nanchang, , China
Research Site, Ningbo, , China
Research Site, Shanghai, , China
Research Site, Shenyang, , China
Research Site, Taiyuan, , China
Research Site, Tianjin, , China
Research Site, Tianjin, , China
Research Site, Wuhan, , China
Research Site, Xi'an, , China
Research Site, Zhengzhou, , China
Research Site, Aarhus N, , Denmark
Research Site, Copenhagen, , Denmark
Research Site, Brest, , France
Research Site, Creteil Cedex, , France
Research Site, Le Mans Cedex, , France
Research Site, Lille, , France
Research Site, Lyon, , France
Research Site, Marseille Cedex 20, , France
Research Site, Montpellier, , France
Research Site, Paris Cedex 18, , France
Research Site, Rouen, , France
Research Site, Saint Herblain, , France
Research Site, Strasbourg, , France
Research Site, Toulouse, , France
Research Site, Berlin, , Germany
Research Site, Essen, , Germany
Research Site, Gauting, , Germany
Research Site, Georgsmarienhuette, , Germany
Research Site, Heidelberg, , Germany
Research Site, Köln, , Germany
Research Site, Muenster, , Germany
Research Site, Alessandria, , Italy
Research Site, Bari, , Italy
Research Site, Bergamo, , Italy
Research Site, Milan, , Italy
Research Site, Monza, , Italy
Research Site, Orbassano, , Italy
Research Site, Padova, , Italy
Research Site, Parma, , Italy
Research Site, Rozzano, , Italy
Research Site, Varese, , Italy
Research Site, Amagasaki-shi, , Japan
Research Site, Hiroshima-shi, , Japan
Research Site, Kitakyushu-shi, , Japan
Research Site, Matsuyama-shi, , Japan
Research Site, Nagoya-shi, , Japan
Research Site, Nishinomiya-shi, , Japan
Research Site, Okayama-shi, , Japan
Research Site, Osakasayama-shi, , Japan
Research Site, Tokyo, , Japan
Research Site, Ube-shi, , Japan
Research Site, Cheongju-si, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Amsterdam, , Netherlands
Research Site, Eindhoven, , Netherlands
Research Site, Rotterdam, , Netherlands
Research Site, Lørenskog, , Norway
Research Site, Oslo, , Norway
Research Site, Bydgoszcz, , Poland
Research Site, Bystra, , Poland
Research Site, Olsztyn, , Poland
Research Site, Poznań, , Poland
Research Site, Rzeszów, , Poland
Research Site, Warszawa, , Poland
Research Site, Amanzimtoti, , South Africa
Research Site, Johannesburg, , South Africa
Research Site, Kraaifontein, , South Africa
Research Site, Parktown, , South Africa
Research Site, Pretoria, , South Africa
Research Site, Pretoria, , South Africa
Research Site, Barakaldo, , Spain
Research Site, Barcelona, , Spain
Research Site, Madrid, , Spain
Research Site, Oviedo, , Spain
Research Site, Baden, , Switzerland
Research Site, Basel, , Switzerland
Research Site, Bern, , Switzerland
Research Site, Fribourg, , Switzerland
Research Site, St. Gallen, , Switzerland
Research Site, Kaohsiung, , Taiwan
Research Site, Taichung, , Taiwan
Research Site, Tainan City, , Taiwan
Research Site, Taipei, , Taiwan
Research Site, Adana, , Turkey
Research Site, Ankara, , Turkey
Research Site, Ankara, , Turkey
Research Site, Diyarbakir, , Turkey
Research Site, Izmir, , Turkey
Research Site, Cambridge, , United Kingdom
Research Site, Leeds, , United Kingdom
Research Site, Leicester, , United Kingdom
Research Site, London, , United Kingdom
Research Site, London, , United Kingdom
Research Site, Manchester, , United Kingdom
Research Site, Middlesborough, , United Kingdom
Research Site, Newcastle-upon-Tyne, , United Kingdom
Research Site, Portsmouth, , United Kingdom
Research Site, Taunton, , United Kingdom
Contact Details
Name: Marjorie G Zauderer, MD
Affiliation: Memorial Slone Kettering (MSK) Cancer Centre, NY
Role: PRINCIPAL_INVESTIGATOR
Name: Arnaud Scherpereel, MD
Affiliation: Lille University
Role: PRINCIPAL_INVESTIGATOR
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