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Brief Title: A Study of Nivolumab or Nivolumab Plus Experimental Medication BMS-986205 With or Without Bacillus Calumette-Guerin (BCG) in BCG Unresponsive Bladder Cancer That Has Not Invaded Into the Muscle Wall of the Bladder
Official Title: A Phase 2, Randomized, Open-label Study of Nivolumab or Nivolumab/BMS-986205 Alone or Combined With Intravesical BCG in Participants With BCG-Unresponsive, High-Risk, Non-Muscle Invasive Bladder Cancer
Study ID: NCT03519256
Brief Summary: A study to evaluate the safety and tolerability of nivolumab or nivolumab Plus BMS-986205 with or without BCG in BCG-Unresponsive non-muscle invasive Bladder Cancer.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Local Institution - 0044, Los Angeles, California, United States
Local Institution - 0081, Riverside, California, United States
Local Institution - 0087, San Francisco, California, United States
Local Institution - 0125, Tampa, Florida, United States
Local Institution - 0056, Hapeville, Georgia, United States
Local Institution - 0023, New Lenox, Illinois, United States
Wichita Urology Group, Wichita, Kansas, United States
Local Institution - 0001, Baltimore, Maryland, United States
Local Institution - 0077, Ann Arbor, Michigan, United States
Local Institution - 0032, Minneapolis, Minnesota, United States
Local Institution - 0040, Omaha, Nebraska, United States
Local Institution - 0144, New Brunswick, New Jersey, United States
Deleware Valley Urology, LLC, Voorhees, New Jersey, United States
Local Institution - 0051, New York, New York, United States
Local Institution - 0058, Columbus, Ohio, United States
Local Institution - 0036, Bala-Cynwyd, Pennsylvania, United States
Local Institution - 0049, Charleston, South Carolina, United States
Local Institution - 0002, Myrtle Beach, South Carolina, United States
Local Institution - 0057, Chattanooga, Tennessee, United States
Urology Clinics Of North Texas, Pa, Dallas, Texas, United States
Local Institution - 0048, Houston, Texas, United States
Local Institution - 0140, Houston, Texas, United States
Local Institution - 0047, Lubbock, Texas, United States
Urology San Antonio Research, Pa, San Antonio, Texas, United States
Local Institution - 0141, Seattle, Washington, United States
Local Institution - 0068, Capital Federal, Buenos Aires, Argentina
Local Institution - 0065, Capital Federal, Distrito Federal, Argentina
Local Institution - 0089, Ciudad Autonoma Buenos Aires, Distrito Federal, Argentina
Local Institution, Viedma, RIO Negro, Argentina
Instituto Oncologico De Cordoba, Cordoba, , Argentina
Local Institution - 0137, Mendoza, , Argentina
Local Institution - 0146, Camperdown, New South Wales, Australia
Local Institution - 0148, St Leonards, New South Wales, Australia
Local Institution - 0072, Fortaleza, Ceara, Brazil
Local Institution - 0151, Curitiba, Parana, Brazil
Local Institution - 0073, Porto Alegre, RIO Grande DO SUL, Brazil
Local Institution, Itacorubi, Florianopolis, Santa Catarina, Brazil
Local Institution - 0078, Jau, Sao Paulo, Brazil
Local Institution - 0150, Rio de Janeiro, , Brazil
Local Institution - 0074, Sao Paulo, , Brazil
Local Institution - 0143, North York, Ontario, Canada
Local Institution - 0086, Toronto, Ontario, Canada
Local Institution - 0084, Toronto, Ontario, Canada
Local Institution - 0046, Quebec City, Quebec, Canada
Local Institution - 0154, Santiago, Metropolitana, Chile
Local Institution - 0069, Santiago, Metropolitana, Chile
Local Institution - 0128, Beijing, Beijing, China
Local Institution - 0131, Beijing, Beijing, China
Local Institution - 0116, Beijing, Beijing, China
Local Institution - 0099, Beijing, Beijing, China
Local Institution - 0129, Chongqing, Chongqing, China
Local Institution - 0108, Fuzhou, Fujian, China
Local Institution - 0117, Guangzhou, Guangdong, China
Local Institution - 0102, Nanjing, Jiangsu, China
Local Institution - 0109, Nan Chang, Jiangxi, China
Local Institution - 0112, Jinan, Shandong, China
Local Institution - 0111, Yantai, Shandong, China
Local Institution - 0098, Shanghai, Shanghai, China
Local Institution - 0094, Shanghai, Shanghai, China
Local Institution - 0097, Shanghai, Shanghai, China
Local Institution - 0120, Chengdu, Sichuan, China
Local Institution - 0133, Tianjin, Tianjin, China
Local Institution - 0126, Hangzhou, Zhejiang, China
Local Institution - 0027, Suresnes, Hauts-de-Seine, France
Local Institution - 0028, Angers, Maine-et-Loire, France
Local Institution - 0031, Bordeaux Cedex, , France
Local Institution - 0088, Lille, , France
Local Institution - 0091, Strasbourg, , France
Local Institution - 0093, Hong Kong, , Hong Kong
IRCCS Istituto Nazionale Tumori Milano, Milano, , Italy
Instituto Nazionale Tumori Fondazione G. Pascale, Napoli, , Italy
Azienda Ospedaliera Universitaria Pisana, Pisa, , Italy
Local Institution - 0062, Tuxtla Gutierrez, Chiapas, Mexico
Local Institution - 0055, Ciudad de Mexico, Distrito Federal, Mexico
Local Institution - 0004, Amsterdam, , Netherlands
Local Institution - 0003, Nijmegen, , Netherlands
Local Institution - 0005, Utrecht, , Netherlands
Local Institution - 0070, Omsk, , Russian Federation
Local Institution - 0054, Saint-Petersburg, , Russian Federation
Local Institution - 0153, Saint-Petersburg, , Russian Federation
Local Institution, Madrid, , Spain
Local Institution - 0033, Malaga, , Spain
Local Institution - 0139, Santander, , Spain
Local Institution - 0136, Valencia, , Spain
Local Institution, Chelmsford, Essex, United Kingdom
Local Institution, London, Greater London, United Kingdom
Local Institution - 0013, Southampton, Hampshire, United Kingdom
Local Institution - 0015, Lancaster, , United Kingdom
Name: Bristol-Myers Squibb
Affiliation: Bristol-Myers Squibb
Role: STUDY_DIRECTOR