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Spots Global Cancer Trial Database for Evolution of Proteomic Profiles of Intestinal Microbiota in Patients With Locally Advanced or Metastatic Urothelial Carcinomas

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Trial Identification

Brief Title: Evolution of Proteomic Profiles of Intestinal Microbiota in Patients With Locally Advanced or Metastatic Urothelial Carcinomas

Official Title: Analysis of the Evolution of Proteomic Profiles of Intestinal Microbiota in Patients With Locally Advanced or Metastatic Urothelial Carcinomas According to Their Response to Immunotherapy (Responders vs. Non-responders) : A Prospective Pilot Study

Study ID: NCT04566029

Study Description

Brief Summary: Immunotherapy has become an essential therapeutic weapon against many cancers. Control point inhibitors (CPI, PD-1/PD-L1) have shown efficacy in the therapeutic management of tumors in the bladder in progression after administering platinum derivatives. But only 20% of patients get any clinical benefit from these heavy treatments in the long term. Treating metastatic patients without distinction means taking a considerable risk of toxicity and generates major costs. It is therefore urgent and important to exceed the current criteria for using immunotherapy. Recent studies have shown the interest of studying intestinal microbiota as a marker of the efficacy of immunotherapy. The investigators hypothesized that the proteomic signature of the intestinal microbiota in patients with locally advanced or metastatic urothelial carcinomas who responded to immunotherapies was special, and has very different characteristics from that of patients with the same pathology who do not respond to immunotherapy.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

ICM parc euromedecine, Montpellier, Hérault, France

Hopital Tenon ( Paris), Paris, Paris Cx 20, France

Institut Sainte Cancerologie Lucien Neuwirth, Avignon, Saint Priest En Jarez, France

ICO-Site Paul Papin, Angers, , France

Institut Bergonié, Bordeaux, , France

Centre Leon Berard, Lyon, , France

Centre Antoine Lacassagne, Nice, , France

HEGP GH Universitaire Paris Ouest, Paris, , France

ICANS Strasbourg, Strasbourg, , France

Iuct Oncopole, Toulouse, , France

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

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