Spots Global Cancer Trial Database for Online Adaptive Radiotherapy Cervical Cancer With Reduced Margin for Cervical Cancer

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Trial Identification

Brief Title: Online Adaptive Radiotherapy Cervical Cancer With Reduced Margin for Cervical Cancer

Official Title: A Prospective Study to Evaluate Online Adaptive Radiotherapy in Cervical Cancer With Reduced Margin

Study ID: NCT05880485

Conditions

Uterine Cervical Neoplasm

Interventions

online adaptive radiotherapy

Study Description

Brief Summary: Online adaptive radiotherapy (oART) has demonstrated to be feasible to reduce planning target volume (PTV) margins for cervical cancer. To explore the value of reduced margins in oART for cervical cancer, we conducted a prospective clinical trial to determine the clinical efficacy and toxicity of reduced margins.

Detailed Description: This is an investigator-initiated efficacious, single-center, open-label clinical trial study. This study hypothesizes that the use of reduced PTV margins in oART for cervical cancer could decrease toxicity and achieve more accurate dosimetric coverage. A dose of 50.4 Gy is delivered to clinical target volume (CTV) with reduced margin oART. Patients receive cisplatin based concurrent chemotherapy. The primary endpoint is acute toxicity.