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Brief Title: An Investigational Immuno-therapy Study of Nivolumab, Compared to Placebo, in Patients With Bladder or Upper Urinary Tract Cancer, Following Surgery to Remove the Cancer
Official Title: A Phase 3 Randomized, Double-blind, Multi-center Study of Adjuvant Nivolumab Versus Placebo in Subjects With High Risk Invasive Urothelial Carcinoma (CheckMate 274: CHECKpoint Pathway and nivoluMAb Clinical Trial Evaluation 274)
Study ID: NCT02632409
Brief Summary: The purpose of this study is to determine the effectiveness and safety of Nivolumab compared to placebo in participants who have undergone radical surgery for invasive urothelial cancer.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Alaska Urological Institute dba Alaska Clinical Research Center, Anchorage, Alaska, United States
Local Institution - 0179, Tucson, Arizona, United States
Local Institution - 0061, Clovis, California, United States
Local Institution - 0172, Sacramento, California, United States
Local Institution - 0005, San Francisco, California, United States
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Local Institution - 0167, Gainesville, Florida, United States
Local Institution - 0030, Miami Beach, Florida, United States
Local Institution - 0008, Tampa, Florida, United States
Local Institution - 0168, Maywood, Illinois, United States
Local Institution - 0094, Fort Wayne, Indiana, United States
Local Institution - 0171, New Orleans, Louisiana, United States
Local Institution - 0173, Grand Rapids, Michigan, United States
Local Institution - 0051, Burnsville, Minnesota, United States
Local Institution - 0004, Rochester, Minnesota, United States
Local Institution - 0003, Omaha, Nebraska, United States
Local Institution - 0177, Las Vegas, Nevada, United States
Local Institution - 0176, Albany, New York, United States
Local Institution - 0157, Buffalo, New York, United States
Local Institution - 0007, Mineola, New York, United States
Local Institution - 0001, New York, New York, United States
Local Institution - 0006, New York, New York, United States
Local Institution - 0166, Chapel Hill, North Carolina, United States
Local Institution, Durham, North Carolina, United States
Local Institution - 0044, Portland, Oregon, United States
Local Institution - 0010, Portland, Oregon, United States
Local Institution - 0180, Tigard, Oregon, United States
Local Institution - 0074, Allentown, Pennsylvania, United States
Local Institution - 0011, Pittsburgh, Pennsylvania, United States
Local Institution - 0040, Pittsburgh, Pennsylvania, United States
Local Institution - 0169, Myrtle Beach, South Carolina, United States
Local Institution - 0009, Chattanooga, Tennessee, United States
Local Institution - 0234, Norfolk, Virginia, United States
Local Institution - 0021, Berazategui, Buenos Aires, Argentina
Local Institution - 0090, Capital Federal, Buenos Aires, Argentina
Local Institution - 0089, Ciudad Autonoma De Buenos Aire, Buenos Aires, Argentina
Local Institution - 0022, Ciudad Autónoma de BuenosAires, Buenos Aires, Argentina
Local Institution - 0102, Viedma, RIO Negro, Argentina
Local Institution - 0020, San Miguel De Tucuman, Tucuman, Argentina
Local Institution - 0048, Liverpool, New South Wales, Australia
Local Institution - 0047, St. Leonards, New South Wales, Australia
Local Institution - 0046, Waratah, New South Wales, Australia
Local Institution - 0050, Elizabeth Vale, South Australia, Australia
Local Institution - 0184, Frankston, Victoria, Australia
Local Institution - 0175, Perth, Western Australia, Australia
Local Institution - 0133, Linz, , Austria
Local Institution - 0136, Salzburg, , Austria
Local Institution - 0132, Vienna, , Austria
Local Institution - 0183, Wien, , Austria
Local Institution - 0029, Hasselt, , Belgium
Local Institution - 0027, Liege, , Belgium
Local Institution - 0071, Ijui, RIO Grande DO SUL, Brazil
Local Institution - 0072, Porto Alegre, RIO Grande DO SUL, Brazil
Local Institution - 0070, Barretos, Sao Paulo, Brazil
Local Institution - 0073, Cerqueira Cesar, SAO Paulo, Brazil
Local Institution - 0231, Rio De Janeiro, , Brazil
Local Institution - 0100, São Paulo, , Brazil
Local Institution - 0139, Edmonton, Alberta, Canada
Local Institution - 0109, Montreal, Quebec, Canada
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Local Institution - 0101, Montreal, , Canada
Local Institution - 0099, Santiago, Metropolitana, Chile
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Local Institution - 0137, Temuco, , Chile
Local Institution - 0191, Beijing, Beijing, China
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Local Institution - 0210, Chongqing, Chongqing, China
Local Institution - 0198, Fuzhou, Fujian, China
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Local Institution - 0227, Nanning, Guangxi, China
Local Institution - 0196, Wuhan, Hubei, China
Local Institution - 0220, Nanjing, Jiangsu, China
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Local Institution, Xi'an, Shan3xi, China
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Local Institution - 0230, Wenzhou, Zhejiang, China
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Local Institution - 0091, Medellin, , Colombia
Local Institution - 0108, Aalborg, , Denmark
Local Institution - 0106, Aarhus N, , Denmark
Local Institution - 0107, Copenhagen, , Denmark
Local Institution - 0233, Clermont-ferrand, , France
Local Institution - 0115, La Roche-sur-Yon, , France
Local Institution - 0080, Marseille Cedex 9, , France
Local Institution - 0081, Paris, , France
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Local Institution - 0098, Villejuif, , France
Local Institution - 0131, Chemnitz, , Germany
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Local Institution - 0122, Munich, , Germany
Local Institution - 0185, Nuernberg, , Germany
Local Institution - 0130, Regensburg, , Germany
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Local Institution - 0054, Wilton, Cork, Ireland
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Local Institution - 0120, Ramat Gan, , Israel
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Local Institution - 0088, Arezzo, , Italy
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Local Institution - 0189, Reggio Emilia, , Italy
Local Institution - 0085, Roma, , Italy
Local Institution - 0086, Roma, , Italy
Local Institution - 0083, Siena, , Italy
Local Institution - 0142, Akita-shi, Akita, Japan
Local Institution - 0144, Hirosaki, Aomori, Japan
Local Institution - 0162, Fukuoka-shi, Fukuoka, Japan
Local Institution - 0161, Sapporo-shi, Hokkaido, Japan
Local Institution - 0160, Sapporo, Hokkaido, Japan
Local Institution - 0148, Tsukuba-shi, Ibaraki, Japan
Local Institution - 0163, Nagasaki-shi, Nagasaki, Japan
Local Institution - 0150, Niigata-shi, Niigata, Japan
Local Institution - 0141, Okayama-city, Okayama, Japan
Local Institution - 0149, Osakasayama, Osaka, Japan
Local Institution - 0151, Hamamatasu, Shizuoka, Japan
Local Institution - 0146, Bunkyo-ku, Tokyo, Japan
Local Institution - 0145, Shinjuku-Ku, Tokyo, Japan
Local Institution - 0147, Shinjuku-ku, Tokyo, Japan
Local Institution - 0143, Chiba, , Japan
Local Institution - 0164, Osaka, , Japan
Local Institution - 0155, Seongnam-si, , Korea, Republic of
Local Institution - 0154, Seoul, , Korea, Republic of
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Local Institution - 0138, Df, Distrito Federal, Mexico
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Local Institution - 0035, Guadalajara, Jalisco, Mexico
Local Institution - 0032, Monterrey, Nuevo Leon, Mexico
Local Institution - 0069, Amsterdam, , Netherlands
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Local Institution - 0041, Nijmegen, , Netherlands
Local Institution - 0043, Lima, , Peru
Local Institution - 0055, Gdansk, , Poland
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Local Institution - 0096, Craiova, , Romania
Local Institution - 0078, Floresti, , Romania
Local Institution - 0181, Timisoara, Timis, , Romania
Local Institution - 0140, Moscow, , Russian Federation
Local Institution - 0031, Saint-Petersburg, , Russian Federation
Local Institution - 0067, Badalona-barcelona, , Spain
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Local Institution - 0158, Kaohsiung, , Taiwan
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Local Institution - 0025, Manchester, Greater Manchester, United Kingdom
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Local Institution - 0024, Sutton, Surrey, United Kingdom
Local Institution - 0059, Sheffield, Yorkshire, United Kingdom
Local Institution - 0036, London, , United Kingdom
Local Institution - 0114, London, , United Kingdom
Name: Bristol-Myers Squibb
Affiliation: Bristol-Myers Squibb
Role: STUDY_DIRECTOR