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Brief Title: A Study to Evaluate the Safety and Efficacy of Nivolumab Monotherapy and Nivolumab in Combination With Ipilimumab in Pediatric Participants With High Grade Primary Central Nervous System (CNS) Malignancies
Official Title: Phase Ib /II Clinical Trial of Nivolumab Monotherapy and Nivolumab in Combination With Ipilimumab in Pediatric Subjects With High Grade Primary CNS Malignancies
Study ID: NCT03130959
Brief Summary: The purpose of this study is to determine the safety and effectiveness of nivolumab alone and in combination with ipilimumab in pediatric patients with high grade primary central nervous system (CNS) malignancies.
Detailed Description:
Minimum Age: 6 Months
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
Local Institution - 0057, Los Angeles, California, United States
Local Institution - 0016, Aurora, Colorado, United States
Local Institution - 0046, Gainesville, Florida, United States
Local Institution - 0011, Chicago, Illinois, United States
Local Institution - 0005, Baltimore, Maryland, United States
Local Institution - 0043, Boston, Massachusetts, United States
Local Institution - 0044, Saint Louis, Missouri, United States
Local Institution - 0004, New York, New York, United States
Local Institution - 0017, New York, New York, United States
Cincinnati Children'S Hospital Medical Center, Cincinnati, Ohio, United States
Local Institution - 0066, Philadelphia, Pennsylvania, United States
Local Institution, Charleston, South Carolina, United States
Local Institution - 0012, Memphis, Tennessee, United States
Local Institution - 0042, Houston, Texas, United States
Local Institution - 0022, Randwick, New South Wales, Australia
Local Institution - 0035, Sth Brisbane, Queensland, Australia
Local Institution, Clayton, Victoria, Australia
Local Institution - 0034, Parkville, Victoria, Australia
Local Institution - 0033, Nedlands, Western Australia, Australia
Local Institution - 0052, Porto Alegre, RIO Grande DO SUL, Brazil
Local Institution - 0051, Barretos, Sao Paulo, Brazil
Local Institution - 0053, Ribeirao Preto, Sao Paulo, Brazil
Local Institution - 0049, Sao Paulo, , Brazil
Local Institution - 0050, Sao Paulo, , Brazil
Local Institution - 0021, Toronto, Ontario, Canada
Local Institution - 0001, Montreal, Quebec, Canada
Local Institution - 0002, Quebec, , Canada
Local Institution - 0028, Angers, , France
Local Institution - 0029, Bordeaux Cedex, , France
Local Institution - 0027, Lille, , France
Local Institution - 0025, Lyon, , France
Local Institution - 0024, Marseille, , France
Local Institution - 0023, Paris, , France
Local Institution - 0064, Vandoeuvre les Nancy, , France
Local Institution - 0026, VIillejuif, , France
Local Institution - 0060, Essen, , Germany
Local Institution - 0061, Hamburg, , Germany
Local Institution - 0063, Heidelberg, , Germany
Local Institution - 0062, Wuerzburg, , Germany
Local Institution - 0018, Hong Kong, , Hong Kong
Local Institution - 0059, Haifa, , Israel
Local Institution - 0058, Ramat Gan, , Israel
Local Institution - 0007, Rotterdam, , Netherlands
Local Institution - 0008, Utrecht, , Netherlands
Local Institution - 0067, Oslo, , Norway
Local Institution - 0047, Warszawa, , Poland
Local Institution - 0048, Moscow, , Russian Federation
Local Institution - 0037, Esplugues de Llobregat, , Spain
Local Institution - 0038, Madrid, , Spain
Local Institution - 0036, Valencia, , Spain
Local Institution - 0065, Solna, , Sweden
Local Institution - 0010, London, Greater London, United Kingdom
Local Institution - 0013, Liverpool, Merseyside, United Kingdom
Local Institution - 0015, Newcastle Upon Tyne, Tyne And Wear, United Kingdom
Name: Bristol-Myers Squibb
Affiliation: Bristol-Myers Squibb
Role: STUDY_DIRECTOR