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Spots Global Cancer Trial Database for Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function

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Trial Identification

Brief Title: Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function

Official Title: Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With no Measurable Remaining Vestibular Function

Study ID: NCT02415257

Interventions

Gentamicin

Study Description

Brief Summary: The purpose of the study is to determine whether vestibular and postural compensation following schwannoma surgery is improved by ablating vestibular function prior to surgery, even if vestibular function is absent according to modern assessment techniques

Detailed Description: Patients subjected to vestibular schwannoma surgery most often suffer from vertigo after surgery, even if no vestibular function can be found in pre-surgical assessment. According to retrospective data about 33% of patients scheduled for surgery do not have any measurable vestibular function. Even the occurrence of spontaneous nystagmus has been recorded in patients with no or very little function prior to surgery (Parietti-Winkler et al. 2008 JNNP). This indicates that despite new methods of measuring vestibular function, remaining vestibular function can be present and patients might benefit from pre-treatment of gentamicin (Tjernström et al. 2009 JNNP)

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Dept. OtoRhinoLaryngology Head and Neck Surgery, Skane University Hospital, Lund, , Sweden

Contact Details

Name: Fredrik Tjernström, MD, PhD

Affiliation: Lund University

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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