Spots Global Cancer Trial Database for Investigating the Safety and Efficacy of Rituximab and Pembrolizumab in Relapsed/Refractory Waldenström's Macroglobulinaemia
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Trial Identification
Brief Title: Investigating the Safety and Efficacy of Rituximab and Pembrolizumab in Relapsed/Refractory Waldenström's Macroglobulinaemia
Official Title: A Phase II Trial to Investigate the Safety and Efficacy of Rituximab and Pembrolizumab in Relapsed/Refractory Waldenström's Macroglobulinaemia
Study ID: NCT03630042
Conditions
Study Description
Brief Summary: This study is for patients who have previously been treated for Waldenström's macroglobulinaemia (WM) and their disease has either not responded (known as refractory disease) or has returned (known as relapsed disease). Through this study, the researchers would like to find out whether treating these patients with drugs called rituximab and pembrolizumab is a safe and effective combination for this disease. In this study, pembrolizumab and rituximab will be given together. In other studies pembrolizumab has been shown to be effective at treating diseases similar to WM. The researchers want to test whether giving pembrolizumab and rituximab together is safe and effective.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Derriford Hospital, Univeristy Hospitals Plymouth NHS Trust, Plymouth, Devon, United Kingdom
Torbay and South Devon NHS Foundation Trust, Torquay, Devon, United Kingdom
Royal Bournemouth Hospital, University Hospitals Dorset NHS Foundation Trust, Bournemouth, Dorset, United Kingdom
St Bartholomew's Hospital, Barts Health NHS Trust, London, Greater London, United Kingdom
UCLH, Univeristy College London Hospitals NHS Foundation Trust, London, Greater London, United Kingdom
The Christie Hospital, The Christie NHS Foundation Trust, Manchester, Greater Manchester, United Kingdom
Churchill Hospital, Oxford Univeristy NHS Foundation Trust, Oxford, Oxfordshire, United Kingdom
Bristol Haematology & Oncology Medical Centre, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, , United Kingdom
Norfolk and Norwich University Hospital, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, , United Kingdom
Contact Details
Name: Jaimal Kothari
Affiliation: Oxford University Hospitals NHS Trust
Role: PRINCIPAL_INVESTIGATOR
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