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Spots Global Cancer Trial Database for Collaborative Wilms Tumour Africa Project

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Trial Identification

Brief Title: Collaborative Wilms Tumour Africa Project

Official Title: Collaborative Wilms Tumour Africa Project

Study ID: NCT01991652

Conditions

Wilms Tumour

Interventions

Study Description

Brief Summary: Significant progress has been made in the treatment of Wilms tumor in high income countries, where survival is now around 85% - 90%. Survival in low income countries is much lower; specific challenges include late presentation, malnutrition, less intense supportive care facilities and failure to complete treatment. A comprehensive treatment guideline was introduced in Malawi in 2006 which included nutritional support and social support to enable parents to complete treatment. Survival has increased to around 50%; 95% of children completed their treatment. A multi-disciplinary group of African clinicians and 'state of the art' experts produced a consensus treatment guideline for children with Wilms tumor in sub-Saharan Africa. This guideline will be implemented as a multi-center prospective clinical trial in 2014 in six - eight institutes, expecting about 200 new patients per year. The hypothesis is that 2 year event free survival will be 50%, with \<10% failure to complete treatment and \<10% treatment related mortality. Other research questions include efficacy and toxicity of preoperative chemotherapy and the comparison of surgical staging, local pathology and central review pathology in stratifying postoperative chemotherapy.

Detailed Description: Patients are treated according to standard care. Data are documented on presentation at diagnosis, response of the tumor, findings at surgery and pathology, treatment given and outcome of the patients.

Eligibility

Minimum Age:

Eligible Ages: CHILD, ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Mbingo Mission Hospital, Bamenda, , Cameroon

Korle Bu Hospital, Accra, , Ghana

College of Medicine, Blantyre, , Malawi

Contact Details

Name: Trijn Israels, MD PhD

Affiliation: Amsterdam UMC, location VUmc

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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