Neoplasms

All Conditions

Symptoms and General Pathology

Skin and Connective Tissue Diseases

Rare Diseases

Osteosarcoma

Neoplasm Metastasis

Necrosis

Neoplasms, Bone Tissue

Neoplasms, Connective Tissue

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Sarcoma

Soft Tissue Sarcoma

Bone Density Conservation Agents

All Drugs and Chemicals

Zoledronic Acid

Xiaobo Yan, Dr.

Xiaobo Yan

zhaoming Ye, Prof.

Zoledronic acid is an adjuvant treatment for primary osteosarcoma. Zoledronic acid has been widely used in the treatment of metastatic bone tumors. In addition to its inhibition of tumor osteoclasis, it also produces certain killing of tumor cells. effect. Foreign studies have shown that zoledronic acid also has a killing effect on osteosarcoma and has a certain inhibitory effect on distant metastasis. We hope that it can reduce tumor recurrence and lung metastasis through this study.

Zoledronic Acid in Decrease the Lung Metastatic Rate of Osteosarcoma

The Efficacy of New Adjuvant Chemotherapy of Osteosarcoma Combined With Zoledronic Acid in Decrease the Lung Metastatic Rate of Osteosarcoma

Discovery the rate of neonatal lung metastases by high-resolution chest CT

Local recurrence rate of tumor or rate of distant metastasis

the rate of patients that postoperative tumor necrosis rate was estimated to be lower than grade III（90%）

Second Affiliated Hospital, School of Medicine, Zhejiang University

Professor

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Carcinoma

Carcinoma, Renal Cell

Neovascularization, Pathologic

Neoplasms, Glandular and Epithelial

Adenocarcinoma

Kidney Neoplasms

Urologic Neoplasms

Urogenital Neoplasms

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Kidney Diseases

Urologic Diseases

Male Urogenital Diseases

Metaplasia

Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Antineoplastic Agents

Sunitinib

C.M.L. van Herpen, MD, PhD

The purpose of the study is to assess the effect of Sunitinib on tumor vascularization and necrosis in patients with metastatic renal cell cancer.

Sutent is an angiogenesis inhibitor used in the treatment of renal cell cancer. Very often tumor necrosis is seen after the start of the treatment. It is unknown after how many days this effect starts. In patients with renal cell cancer with metastases, who will be treated with Sutent, 3 MRIs will be made. Kep, R2\*, b-coefficient (perfusion, hypoxia, blood volume and necrosis) will be measured.

Influence of Sutent on Tumor Vascularization and Necrosis in Patients With Renal Cell Carcinoma

Pilot Study on the Influence of Sutent on Tumor Vascularization and Necrosis in Patients With Renal Cell Carcinoma

Novo Nordisk A/S

Radboud University Medical Center

C.M.L. van Herpen,

Digestive System Diseases

Carcinoma, Hepatocellular

Liver Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Liver Diseases

Hematinics

Chlorotrianisene

Liver Extracts

transcatheter arterial chemoembolization after liver resection

transcatheter arterial chemoembolization

Micronecrosis is a novel pathological feature of hepatocellular carcinoma (HCC). This study was aimed at evaluating the effect of tumor micronecrosis on postoperative transcatheter arterial chemoembolization (TACE) in patients with hepatocellular carcinomas, and further exploring the value of micronecrosis for guiding TACE in HCC management.

Effect of Tumor Micronecrosis on Postoperative Transcatheter Arterial Chemoembolization in Patients With Hepatocellular Carcinomas

The Guiding Value of Tumor Micronecrosis for Using Postoperative Transcatheter Arterial Chemoembolization in Patients With Hepatocellular Carcinomas

the number of months from the date of surgery to the date of the last follow-up visit or time of death.

the number of months from the date of surgery to the date of first confirmable recurrence or death

Zhejiang University

FACS

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Zoledronic Acid in Decrease the Lung Metastatic Rate of Osteosarcoma	NCT03932071	Lung Metastases Tumor Necrosis	Zoledronic Acid	-	Second Affiliated Hospital, School of Medicine, Zhejiang University
Influence of Sutent on Tumor Vascularization and Necrosis in Patients With Renal Cell Carcinoma	NCT00509704	Renal Cell Canc...		18 Years -	Radboud University Medical Center
Influence of Sutent on Tumor Vascularization and Necrosis in Patients With Renal Cell Carcinoma	NCT00509704	Renal Cell Canc...		18 Years -	Radboud University Medical Center
Effect of Tumor Micronecrosis on Postoperative Transcatheter Arterial Chemoembolization in Patients With Hepatocellular Carcinomas	NCT05352204	Carcinoma, Hepa...	transcatheter a...	-	Zhejiang University
Effect of Tumor Micronecrosis on Postoperative Transcatheter Arterial Chemoembolization in Patients With Hepatocellular Carcinomas	NCT05352204	Carcinoma, Hepa...	transcatheter a...	-	Zhejiang University
Effect of Tumor Micronecrosis on Postoperative Transcatheter Arterial Chemoembolization in Patients With Hepatocellular Carcinomas	NCT05352204	Carcinoma, Hepa...	transcatheter a...	-	Zhejiang University

Spots Global Cancer Trial Database for tumor necrosis