Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Lung Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Treated by traditional video assisted thoracoscopic three-port pulmonary resection in the centers with enough experience in VATS and the volume ≧50 cases each year.

Treated by minimally invasive video assisted thoracoscopic single-port pulmonary resection in the centers with enough experience in VATS and the volume ≧50 cases each year.

Uniportal video-assisted thoracoscopic surgery

Triportal pulmonary resection surgery

Triportal video-assisted thoracoscopic surgery

Uniportal pulmonary resection surgery

Juwei Mu, MD

Lanjun Zhang, MD

Zhidong Liu, MD

Yang Liu, MD

Jiaqing Xiang, MD

Lung cancer is one of the most common cancers in the world. At present, surgical resection is still the standard treatment for early stage lung cancer. Triportal thoracoscopic lung resection is a routine surgically procedure for early stage lung cancer while uniportal thoracoscopic lung resection is developing rapidly in recent years. Although uniportal VATS pulmonary resection has been proven to be effective in preventing postoperative morbidities, there is still no ample evidences to demonstrate that uniportal VATS pulmonary resection is equal or superior to traditional triportal thoracoscopic pulmonary resection. The purpose of this multicenter randomized controlled trial study is to compare the uniportal VATS with traditional triportal VATS pulmonary resection in postoperative complications, long-term survival, lymph node dissection and local recurrence.

Lung cancer is one of the most common cancers in the world，especially in China, where the mortality ranked first in malignant tumors whether for males or females. At present, VATS (Video-assisted thoracoscopic surgery) lobectomy is still the "gold standard" for the treatment of lung cancer. Triportal thoracoscopic lung resection is a routine surgically procedure for early stage lung cancer while uniportal thoracoscopic lung resection is developing rapidly in recent years. Retrospective study in recent years showed that the postoperative complication rate is similar between uniportal thoracoscopic surgery and triportal thoracoscopic surgery. Meanwhile, the incision is more pleasing, the inflammatory response may be milder and the hospitalization time may be shorter in the uniportal thoracoscopic surgery. But until now there is no result of the randomized controlled study on the effectiveness and the prognosis between uniportal thoracoscopic surgery and triportal thoracoscopic surgery to support this conclusion. The objective of this multicenter randomized controlled trial study is to compare the postoperative complications, long-term survival, local recurrence, other perioperative variables such as conversion rate, blood loss, lymph nodes retrieved and postoperative hospital stay between the triportal VATS pulmonary resection and uniportal VATS pulmonary resection on early stage lung cancer.

Uniportal Versus Triportal Thoracoscopic Lobectomy and Sublobectomy for Early Stage Lung Cancer

Uniportal Versus Triportal Thoracoscopic Lobectomy and Sublobectomy for Early Stage Lung Cancer: a Multicenter Randomized Controlled Trial

These respiratory complications involve respiratory distress or failure after the operation with continuation of mechanical ventilation, pulmonary atelectasis requiring sputum suction by bronchoscopy, pneumonia requiring specific antibiotics confirmed by thoracic X-ray or CT scan of the thorax and a positive sputum culture, and acute respiratory distress syndrome.

During the surgery, lymph node dissection were performed. The number of removed lymph-nodes were recorded according to the postoperative pathological diagnosis, and the stations of the lymph node were recorded according to the International Association for the Study of Lung Cancer (IASLC) Lymph Node Map.

three-year local recurrence rate after surgery

Sun Yat-sen University

Fudan University

Chinese PLA General Hospital

Beijing Chest Hospital

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

MD，PHD

Mediastinal Neoplasms

Mediastinal Diseases

Thoracic Diseases

Thoracoscopic surgery performed with the fashion of single 2.5-3.5 cm intercostal incision and 1-2 additional 2-3 mmm needlescopic ports.

Conventional uniportal VATS with single 2.5-3.5 cm intercostal incision

Video-assisted thoracoscopic surgery for pulmonary or mediastinal lesions.

Thoracoscopic surgery

Chiu-kuei Nien

The investigators' study aims is to evaluate the safety and efficacy of uniportal VATS under assistance of needlescopic instruments through additional 2-3 mm ports compared to conventional uniportal VATS in patients with lung lesions.

Needlescopic-assisted Uniportal vs Uniportal VATS

Needlescopic-assisted Uniportal VATS Versus Conventional Uniportal VATS. A Randomized Prospective Noninferiority Study

Post-operative day 3 pain scale documented using Visual Analogue Scale (VAS)

Post-operative day 5 pain scale documented using Visual Analogue Scale (VAS)

Out patient documented using PainDETECT questionnaire (PD-Q)

Total opioid equivalent dose used during post-operative course

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Uniportal Versus Triportal Thoracoscopic Lobectomy and Sublobectomy for Early Stage Lung Cancer	NCT02933294	Lung Neoplasms	Triportal pulmo... Uniportal pulmo...	18 Years -	Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Uniportal Versus Triportal Thoracoscopic Lobectomy and Sublobectomy for Early Stage Lung Cancer	NCT02933294	Lung Neoplasms	Triportal pulmo... Uniportal pulmo...	18 Years -	Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Needlescopic-assisted Uniportal vs Uniportal VATS	NCT03439696	Lung Cancer Lung Cancer Met... Bullous Disease... Nodule Solitary... Mediastinal Tum...	Thoracoscopic s...	20 Years - 90 Years	National Taiwan University Hospital Hsin-Chu Branch
Needlescopic-assisted Uniportal vs Uniportal VATS	NCT03439696	Lung Cancer Lung Cancer Met... Bullous Disease... Nodule Solitary... Mediastinal Tum...	Thoracoscopic s...	20 Years - 90 Years	National Taiwan University Hospital Hsin-Chu Branch

Spots Global Cancer Trial Database for uniportal

Every month we try and update this database with for uniportal cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for uniportal

Every month we try and update this database with for uniportal cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for uniportal cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.