Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Uterine Cervical Neoplasms

Endometrial Neoplasms

Uterine Neoplasms

Genital Neoplasms, Female

Urogenital Neoplasms

Uterine Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Uterine Cervical Diseases

Vaginal vault brachytherapy, associated or not with external beam radiotherapy.

HDR planning using simple radiograph (2D)

2D HDR planning

HDR planning using computed tomography (3D)

3D HDR planning

Demonstrate the limitations of conventional dosimetry (2D) for the adjuvant brachytherapy treatment and assess whether tridimensional dosimetry relates more faithfully with the occurrence of adverse effects.

Radiotherapy is part of a multidisciplinary strategy to fight cancer in all stages, using ionizing radiation to cause damage in tumor cells. After radical surgical treatment of gynecological tumors, pathological findings, such as extension of the myometrium invasion, histologic grade, and vascular- lymphatic invasion predict the risk of locoregional recurrence of disease and, consequently, the need for adjuvant treatment. There are two main methods of adjuvant therapy after hysterectomy for malignant neoplasm of the cervix or endometrium: external beam radiotherapy with or without booster dose of vaginal vault brachytherapy or brachytherapy alone. There are few data in the literature and clinical experience with brachytherapy dimensional (3D) for adjuvant treatment of vaginal vault .

Objective: To demonstrate the limitations of conventional dosimetry (2D) for the adjuvant brachytherapy treatment and assess whether tridimensional dosimetry relates more faithfully with the occurrence of adverse effect.

Methods: A prospective study in the Department of Radiation Oncology, Antonio Candido Camargo Cancer Center will be developed with an expected duration of 14 months and will include 60 patients. Dosimetric parameters of brachytherapy treatment of vaginal vault, able to influence the incidence of adverse effects will be evaluated. Computed tomography for planning of external beam radiotherapy and brachytherapy planning will be used, after placement of intra- vaginal applicator and urinary catheter. For planning brachytherapy two fast acquisition sequences, one with a urinary catheter not pulled and pulled another with the probe will be obtained. The prescription dose obey the standard indication of document of the International Commission on Radiation Units \& Measurements (ICRU 38).

2D vs 3D Planning for High-Dose Rate (HDR) Gynecological Brachytherapy

Clinical and Dosimetric Comparison of 2D Versus 3D HDR Brachytherapy

Dose in bladder; rectum; small intestine; sigmoid colon; urethra; dose trigone; vaginal cuff.

toxicity associated with the genitourinary tract, using Common Terminology Criteria for Adverse Events v4.0 (CTCAE v4.0)

toxicity associated with the gastrointestinal tract, using Common Terminology Criteria for Adverse Events v4.0 (CTCAE v4.0)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
2D vs 3D Planning for High-Dose Rate (HDR) Gynecological Brachytherapy	NCT02091050	Cervix Cancer Endometrial Can...	2D HDR planning 3D HDR planning	18 Years - 85 Years	AC Camargo Cancer Center
2D vs 3D Planning for High-Dose Rate (HDR) Gynecological Brachytherapy	NCT02091050	Cervix Cancer Endometrial Can...	2D HDR planning 3D HDR planning	18 Years - 85 Years	AC Camargo Cancer Center

Spots Global Cancer Trial Database for vaginal vault brachytherapy