Nervous System Diseases

All Conditions

Symptoms and General Pathology

Neoplasms

Diseases and Abnormalities at or Before Birth

Skin and Connective Tissue Diseases

Rare Diseases

Epilepsy

Sclerosis

Tuberous Sclerosis

Brain Diseases

Central Nervous System Diseases

Hamartoma

Neoplasms, Multiple Primary

Syndrome

Neoplastic Syndromes, Hereditary

Congenital Abnormalities

Malformations of Cortical Development

Nervous System Malformations

Neurocutaneous Syndromes

Heredodegenerative Disorders, Nervous System

Neurodegenerative Diseases

Genetic Diseases, Inborn

Tuberous Sclerosis Complex

Shuli Liang, doctor

Prospective controlled studies to identify clinical epilepsy control, cognitive changes, and safety in VNS treatment of tuberculosis-related epilepsy.

Control group: no clear epilepsy focus in the brain, and medication has been continued.

Surgery group: no clear epilepsy focus in the brain, and VNS for tuberculosis-related epilepsy.

In order to ensure the follow-up of the study and 3 years after the end of the study, 50 cases were collected in each group of the study.

The Effectiveness and Safety of Vagus Nerve Stimulation for TRE

Clinical Evaluation of the Effectiveness and Safety of Vagus Nerve Stimulation for Tuberous Sclerosis Complex Related Epilepsy

The grading made by ILAE for the classification of outcome with respect to epileptic seizures following epilepsy surgery. It contains a total of 6 levels. The higher the level, the worse the result. We will count the percentage of patients at each level.epileptic seizures following epilepsy surgery. It is used for assessing the control of epilepsy.

Wechsler Intelligence Scale is used for the evaluation of IQ

QOLIE-31 is suitable for patients 14 years and older. QOLCE-76 is applied to patients aged 2-13 by parents.

Beijing Tiantan Hospital

The First Hospital of Jilin University

Xuanwu Hospital, Beijing

Capital Medical University

Peking University First Hospital

China-Japan Friendship Hospital

Chinese PLA General Hospital

Fourth Medical Center of PLA General Hospital

Capital Institute of Pediatrics, China

The Second Hospital of Hebei Medical University

Xijing Hospital

First Affiliated Hospital Xi'an Jiaotong University

Children's Hospital of Fudan University

RenJi Hospital

Jining Medical University

Xiamen Humanity Hospital

Xiangya Hospital of Central South University

Wuhan Medical Care Center for Women and Children

Guangdong 999 Brain Hospital

Shenzhen Children's Hospital

Xinqiao Hospital, Army Medical University

West China Hospital

Beijing Children's Hospital

Director of Functional Neurosurgery

Respiratory Tract (Lung and Bronchial) Diseases

Heart and Blood Diseases

Blood and Lymph Conditions

Immune System Diseases

Lung Neoplasms

Multiple Myeloma

Neoplasms, Plasma Cell

Lymphoma

Neoplasms by Histologic Type

Hemostatic Disorders

Blood Coagulation Disorders

Vascular Diseases

Paraproteinemias

Blood Protein Disorders

Hematologic Diseases

Hemorrhagic Disorders

Lymphoproliferative Disorders

Immunoproliferative Disorders

Lymphosarcoma

Patients will receive only caner treatment. No osteopathic treatment.

Patients will receive cancer treatment associated with osteopathic intervention

Osteopathic intervention

CRP assessment

QLQ-C30 questionnaire

Borhane SLAMA, MD

In France, new cancer cases keep on increasing with around 150 000 deaths yearly. Cancer therapy research is constantly evolving. Indeed, several studies explore new treatments or their combination with conventional cancer treatments. But, at the same time, complementary and alternative medicines, as osteopathy, remain little explored upon their role in the combination with conventional therapy.

Several studies showed indirect interaction between vagus nerve and cancer. Firstly, vagus nerve regulates homeostasis and immunity by reducing systemic inflammation while maintaining local inflammation and antitumor effects. Secondly, vagus nerve stimulation increases Heart Rate Variability (HRV). Moreover, a higher HRV is associated with an improvement of vital prognosis in cancer patients. Vagus nerve could be stimulated by noninvasive osteopathic manipulations.

This prospective, monocentric and randomized study is a collaboration between the Centre Hospitalier d'Avignon and the Institut de Formation en Ostéopathie du Grand Avignon. It focuses on using noninvasive osteopathic mobilizations to stimulate vagus nerve. Indeed, this study aims to evaluate effects of vagus nerve osteopathic stimulations on HRV in patients with lung cancer, colorectal cancer, Non Hodgkin Lymphoma or Multiple Myeloma. More specifically, this study will tell us whether vagus nerve noninvasive osteopathic stimulations induce increase of HRV associated with a decrease of systemic inflammation and an improvement of patient's quality of life.

For each cancer type, 30 patients will be included. These patients will be randomized into two groups.

Heart Rate Variability, Vagus Nerve and Cancer

Effects of Vagus Nerve Osteopathic Stimulations on Heart Rate Variability of Cancer Patients

To assess the effect of vagus nerve osteopathic stimulations on Heart Rate Variability

To assess the effect of vagus nerve osteopathic stimulations on systemic inflammatory

To assess the effect of vagus nerve osteopathic stimulations on health related quality of life

Institut de Formation en Ostéopathie du Grand Avignon

Centre Hospitalier Henri Duffaut - Avignon

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
The Effectiveness and Safety of Vagus Nerve Stimulation for TRE	NCT04198207	Tuberous Sclero... Epilepsy		2 Years -	Beijing Children's Hospital
Heart Rate Variability, Vagus Nerve and Cancer	NCT04718610	Lung Cancer Colorectal Canc... Multiple Myelom... Non Hodgkin Lym...	Osteopathic int... CRP assessment QLQ-C30 questio...	18 Years -	Centre Hospitalier Henri Duffaut - Avignon

Spots Global Cancer Trial Database for vagus nerve stimulation