Re-Mission

Pamela M Kato

The purpose of this study is to determine the effects of playing the interactive video game, Re-Mission, on patient outcomes, including adherence to medical treatment regimes, self-care behaviors, quality of life, stress, communication, control, and knowledge.

POPULATION: Approximately 340 patients will be enrolled in this study. Patients will be 13 to 29 years of age with any cancer (original diagnosis or relapse), currently receiving treatment and expected to be on treatment for at least 4 - 6 months following Baseline assessment, and able to communicate effectively in English, Spanish, or French. Approximately 170 patients will be enrolled in each of the two treatment groups. Each group will receive either the "Re-Mission" video game and a popular interactive video game, or just the popular interactive video game.

DESIGN: This is a multi-center, randomized trial, with patients randomized to one of two groups. One group (50% of patients) will receive the active intervention, which is the psycho-educational video game module called Re-Mission and a popular video game (hereafter "RE-MISSION") and another group (50 % of patients) will be in a game control group and receive a popular video game only (hereafter "GAME CONTROL. The games in the RE-MISSION and GAME CONTROL groups are delivered on identical mini, personal computers (hereafter "Mini-PC").

INTERVENTION: Each patient in the RE-MISSION group will be asked to play "Re-Mission" along with the popular video game for at least one hour a week for a period of ten to fourteen weeks. "Re-Mission" presents a 3-D environment in which the player can manipulate a humanoid character inside the virtual body of a patient with cancer. Game-play consists of guiding the character to destroy cancer cells and other "enemies" in the body (e.g., bacteria) while avoiding injury or weakness. During the process of playing the game and guiding the character through a series of missions, the player learns about chemotherapy and other medical treatments, health-promoting self-care behaviors, infections, and pain management. In addition, the game has also been designed to facilitate the patient's ability to share knowledge and concerns with others.

DURATION OF STUDY: 9 -12 months

Evaluation of a Video Game for Adolescents and Young Adults With Cancer

Multi-site Evaluation of a Video Game for Adolescents and Young Adults With Cancer

HopeLab Foundation

Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Nutritional and Metabolic Diseases

Symptoms and General Pathology

Breast Neoplasms

Obesity

Breast Diseases

Skin Diseases

All Drugs and Chemicals

Complement System Proteins

This arm will receive the physical activity intervention, which consists of three individual meetings, weekly brief counseling phone calls for 6 weeks, and provision of a video game console with three active video games.

Participants will receive counseling on self-regulatory skill building that has been adapted to complement the video games used. We anticipate that the games used will consist of fitness, sports, and dance games and will be played on a Wii U console. The games played will be chosen by each participant from a pool of potential appropriate games.

Physical activity intervention

Elizabeth J Lyons, PhD, MPH

The purpose of this study is to test an intervention that uses home console video games to encourage increased physical activity among postmenopausal breast cancer survivors.

This research project includes qualitative and quantitative formative research leading to a randomized controlled feasibility trial of a video game-based physical activity intervention. First, we will investigate exercise protocols implemented over 6 weeks in 20 breast cancer survivors. We will choose a console and six games for inclusion in the trial, based on measured energy expenditure and enjoyment. We will create refined exercise protocols using these games and insights from participants. Second, we will test an intervention that uses active video games for implementation of motivating exercise and provision of behavioral tools (e.g., tracking of progress towards goals). Participants in a pre-pilot trial (N = 10) will receive weekly brief telephone counseling over 6 weeks. Feasibility measurement will include attrition, self-reported acceptability, and objective measures of video game play taken from game console data.

LEVEL UP: Video Games for Activity in Breast Cancer Survivors

LEVEL UP: Leveraging Electronic Videogames for Exercise and Leisure: Understanding Preferences of Breast Cancer Survivors

We will investigate the number of participants who drop out of the intervention group in comparison to similar studies

We will measure acceptability of the intervention components and tools using validated self-report measures and qualitative interviews/focus groups

We will inquire about potential adverse events during counseling calls and assessment visits. Discrete events will be summed, and the number of participants with events will be summed.

We will use objective measures to investigate adherence to game play protocols (console logs, automatic postings to the console social network, etc.)

Minutes of moderate-vigorous physical activity measured over a 7 day period

We will use a six minute walk test to measure fitness

Weight will be measured using a calibrated scale

We will measure autonomous motivation (intrinsic, integrated, identified, etc.) specific to physical activity

We will use the Senior Fitness Test to measure strength and body function

We will use the Functional Assessment of Cancer Therapy - Breast measure to quantify quality of life

National Cancer Institute (NCI)

The University of Texas Medical Branch, Galveston

Participants will receive narrative-based games on a mobile device and telephone counseling (weekly for the first 12 weeks, then once per month until 6 months)

Participants will receive an electronic activity monitor with a mobile device and telephone counseling (weekly for the first 12 weeks, then once per month until 6 months)

The game will target motivation via narrative and game mechanics. It will also encourage self-regulation by providing monitoring and feedback of activity. Counseling will be adapted to specifically reference concepts related to narrative and games.

Game intervention

The electronic activity monitor will monitor steps, and the mobile device will provide basic feedback on progress toward goals. Counseling will be standard and concentrate on self-regulatory skill-building.

Standard intervention

Elizabeth Lyons, PhD, MPH

The purpose of this study is to compare an enhanced intervention that includes narrative and game components to a standard intervention that only targets self-monitoring. These approaches will be tested among postmenopausal breast cancer survivors who are sedentary and overweight.

Habitual physical activity decreases risk of multiple negative health outcomes, including breast cancer recurrence and mortality. It is also associated with better quality of life and reducing negative effects of cancer and cancer treatment. However, most breast cancer survivors do not engage in sufficient physical activity. Behavior change interventions produce short-term increases in activity but have difficulty motivating sustained active lifestyles over longer periods and are not equally effective in women of different races/ethnicities. The purpose of this study is to test a novel intervention that uses video games and storytelling to increase motivation. Video game mechanics increase enjoyment and feelings of autonomy (control), competence, and relatedness to others. All of these feelings are associated with motivation for activity and, in turn, sustained activity over time. Additionally, narrative storytelling is an effective method of persuading individuals to change their behavior. We propose that play of active video games that include compelling storylines will increase physical activity among a diverse sample of postmenopausal breast cancer survivors.

To test this hypothesis, we will conduct a clinical trial that compares the enhanced intervention (story-based video games) to a standard intervention in 90 sedentary, overweight postmenopausal breast cancer survivors. Participants in the enhanced group will receive a mobile device and accessories with two story-based video game applications installed. The games incorporate behavior change strategies such as self-monitoring and feedback while also using game mechanics and a lengthy storyline to motivate physical activity. Participants in the standard group will receive the same mobile device with an electronic activity monitor and its companion feedback application. Both groups will receive brief weekly telephone counseling. By comparing two groups that both receive typical behavior change intervention components (counseling) and a novel electronic intervention, we will be able to investigate the specific effects of game mechanics and storytelling on motivation and physical activity. We will measure changes in physical activity, fitness, function, and quality of life from the beginning of the study to 6 months. We will also investigate further changes during an additional 6 month follow-up period in which participants keep their intervention tools but do not receive any counseling, to measure maintenance of activity. This project will develop and test a promising, innovative intervention that has the potential to be used on a widespread basis in clinical and community settings.

Self-monitoring Activity: a Randomized Trial of Game-oriented Applications

Self-monitoring Activity: a Randomized Trial of Game-oriented Applications (SMARTGOAL)

We will use a 6 minute walk test to measure fitness

We will use the Senior Fitness Test to measure physical function

We will use a computerized PROMIS measure

We will use objective measures to investigate adherence to study protocols (game usage, monitor usage, phone calls completed, assessments attended, etc.)

We will use a computerized PROMIS measure specific to cancer patients/survivors

We will use the Functional Assessment of Cancer Therapy - Breast measure

Behavioral Regulation in Exercise Questionnaire-2 will be used

Participants will report their perceptions of app usability and acceptability in the 6 month questionnaire

Participants will self-report their perceptions of the playfulness of the intervention apps

We will measure the extent to which participants in the narrative group felt narratively engaged in the game's storyline

We will measure the extent to which participants in the narrative group felt like they identified with their game character

Minutes of moderate-vigorous physical activity over a 7 day period

We will measure weight using a calibrated scale

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Evaluation of a Video Game for Adolescents and Young Adults With Cancer	NCT00425139	Neoplasms	Re-Mission	13 Years - 29 Years	HopeLab Foundation
LEVEL UP: Video Games for Activity in Breast Cancer Survivors	NCT02255240	Breast Cancer Obesity	Physical activi...	45 Years - 75 Years	The University of Texas Medical Branch, Galveston
Evaluation of a Video Game for Adolescents and Young Adults With Cancer	NCT00425139	Neoplasms	Re-Mission	13 Years - 29 Years	HopeLab Foundation
LEVEL UP: Video Games for Activity in Breast Cancer Survivors	NCT02255240	Breast Cancer Obesity	Physical activi...	45 Years - 75 Years	The University of Texas Medical Branch, Galveston
Self-monitoring Activity: a Randomized Trial of Game-oriented Applications	NCT02341235	Breast Cancer Obesity	Game interventi... Standard interv...	45 Years - 75 Years	The University of Texas Medical Branch, Galveston
LEVEL UP: Video Games for Activity in Breast Cancer Survivors	NCT02255240	Breast Cancer Obesity	Physical activi...	45 Years - 75 Years	The University of Texas Medical Branch, Galveston

Spots Global Cancer Trial Database for video game

Every month we try and update this database with for video game cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for video game

Every month we try and update this database with for video game cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for video game cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.