Neoplasms

All Conditions

Gland and Hormone Related Diseases

Rare Diseases

Adenoma

Hyperparathyroidism

Hyperparathyroidism, Primary

Parathyroid Neoplasms

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Parathyroid Diseases

Endocrine System Diseases

Endocrine Gland Neoplasms

Head and Neck Neoplasms

Primary Hyperparathyroidism

All Drugs and Chemicals

Parathyroid Hormone

The 3D-VNE model is obtained with VP Planning software (Visible Patient, Strasbourg, France), using DICOM (Digital Imaging and Communications in Medicine) images of contrasted Computed Tomography scan of the neck in operative positioning.

3D-VNE (virtual neck exploration)

Mihaela IGNAT, MD

A prospective database of consecutive patients with hyperparathyroidism subject to surgery is created. Preoperative workup and operative findings are recorded in this registry to allow comprehensive analysis.

This is a non-interventional, prospective, monocentric, non-randomized trial. All patients with biochemically confirmed Primary Hyperparathyroidism (PHPT) who are scheduled for elective parathyroidectomy in the Endocrine and Digestive Surgery Unit of the University Hospital of Strasbourg are considered. Data concerning the age, the operative date, the results of the pre-operative biological work-up (plasma calcium, phosphor, parathyroid hormone (PTH) level, vitamin D), the results of pre-operative imaging (CT (computerized tomography) scan, 99mTc SestaMIBI Scan, 3D-Vitual Neck Exploration (VNE)), the operative data (the surgical approach, the localization and the dimensions of the adenoma (s), the necessity to convert to classical approach and its reason, the values of the intra operative PTH), the pathology results, the biological work-up at follow-up (plasma calcium, phosphor, PTH, vitamin D) are prospectively recorded in the database.

Cohort Trial on Perioperative Localization Techniques of Parathyroid Adenomas

(true positives + true negatives) / number of patients

Sensitivity = True Positives / (True Positives + False Negatives)

Specificity = True Negatives / (True Negatives + False Positives)

Positive predictive value = True Positives / (True Positives + False Positives)

Negative predictive value = True Negatives / (True Negatives + False Negatives)

(True positives + True negatives) / number of patients

Number of patients with minimally invasive parathyroidectomy/ total number of operated patients

Number of patients with classical cervicotomy parathyroidectomy/ total number of operated patients

Number of patients necessitating conversion from minimally invasive parathyroidectomy approach to classical cervicotomy / total number of operated patients

Number of patients with recurrent / total number of operated patients

Spots Global Cancer Trial Database for virtual neck exploration