Neoplasms

All Conditions

Respiratory Tract (Lung and Bronchial) Diseases

Ear, Nose, and Throat Diseases

Behaviors and Mental Disorders

Carcinoma

Carcinoma in Situ

Carcinoma, Squamous Cell

Head and Neck Neoplasms

Laryngeal Diseases

Laryngeal Neoplasms

Respiratory Tract Diseases

Otorhinolaryngologic Diseases

Otorhinolaryngologic Neoplasms

Respiratory Tract Neoplasms

Quality of Life

Transoral CO2-Laser Microsurgical Cordectomy defined by European Laryngological Society (Remacle M, Eckel HE, Antonelli A, et al. Endoscopic cordectomy. A proposal for a classification by the Working Committee, European Laryngological Society. Eur Arch Otorhinolaryngol. 2000;257(4):227-231.)

Single Vocal Cord Irradiation defined by Kwa et al. and Al-Mamgani et al. (Kwa SLS, Al-Mamgani A, Osman SOS, Gangsaas A, Levendag PC, Heijmen BJM. Inter- and Intrafraction Target Motion in Highly Focused Single Vocal Cord Irradiation of T1a Larynx Cancer Patients. Int J Radiat Oncol Biol Phys. 2015;93(1):190-195. Al-Mamgani A, Kwa SLS, Tans L, et al. Single Vocal Cord Irradiation: Image Guided Intensity Modulated Hypofractionated Radiation Therapy for T1a Glottic Cancer: Early Clinical Results. Int J Radiat Oncol Biol Phys. 2015;93(2):337-343.)

The following planning aim will be pursued: full coverage of the PTV with at least 95% of the prescribed dose and a maximum (0.03 cc) PTV dose of \<107%: 16 x 3.63 = 58.08 Gy in 5 fractions per week using 5 to 9 static IMRT or VMAT.

Single Vocal Cord Irradiation (SVCI)

The TLM has to be performed using a CO2 laser, coupled to an operative microscope, at 4-8W in ultrapulse mode. The type of cordectomy performed must be mentioned using the following classification according the classification of the European Laryngological Society.

The type of resection chosen should provide complete removal of the primary lesion with negative margins.

Surgery will generally be performed within 3 weeks after randomization and not more than 6 weeks after panendoscopy.

The extent of the cordectomy must include a complete anterior, posterior, inferior and supero-lateral mucosal and deep soft tissue margin.

Arm A: Transoral CO2-Laser Microsurgical Cordectomy (TLM)

Olgun Elicin, M.D.

Timo Nannen

Jean Bourhis, MD

Mahmut E Ozsahin, MD

Martina Broglie Däppen, PD Dr. med.

Simon Müller, Dr. med.

Olgun Elicin, MD

Laser surgery and radiotherapy are well-established standards of care for unilateral stage 0 \& I carcinoma in situ (Cais) and squamous cell carcinoma of glottic larynx (SCCGL). Based on meta-analyses, functional and oncological outcome after both treatment modalities are comparable1-5. However, no properly conducted randomized trials comparing these treatments exist. The only such trial with the endpoint of voice quality had to be prematurely closed due to low accrual6.

The traditional radiotherapy involves the treatment of the whole larynx. Recently, a new radiotherapy technique was introduced by a team of researchers from Netherlands, where the treated target volume consists of involved vocal cord and therefore 8 to 10-fold smaller than the target volumes used for traditional whole larynx irradiation. The treatment is reduced to 16 fractions which corresponds to 3 weeks and a day7-12. The results of a prospective cohort (n=30) with single vocal cord irradiation (SVCI) were compared with the results of a historical prospective cohort previously treated with whole larynx radiotherapy (n=131) in the same institute. The median follow-up was 30 months. The voice handicap index (VHI) at all time points beginning from the 6th week after SVCI was significantly superior to the same time points with conventional radiotherapy. Moreover, a comparable local control with SVCI (100%) vs. conventional radiotherapy (92%) was reported at two years, p=0.2412.

Based on this information, the investigators' main aim is to compare SVCI to Transoral CO2-Laser Microsurgical Cordectomy (TLM) with the main focus of patient-reported voice quality.

Background and Rationale

Head and neck squamous cell carcinoma (HNSCC) is the 6th most common type of cancer worldwide. Of all head and neck cancers, approximately 30% originates from the larynx. In Europe, annually 52.000 patients are diagnosed with cancer of the larynx. About 50-60% of laryngeal squamous cell carcinomas arise from the glottic region and over 80% of these patients present in an early stage. The larynx has important roles in production of voice, coordination of deglutition, and respiration. Therefore, the treatment aim of laryngeal cancer is not only achievement of maximum disease control, but also maintenance of function. Transoral CO2-Laser Microsurgical Cordectomy (TLM) and radiotherapy are well-established standard treatment modalities for unilateral stage 0-I carcinoma in situ and squamous cell carcinoma of glottic larynx (for convenience, both will be mentioned as SCCGL throughout this protocol). Based on various clinical studies and meta-analyses, functional and oncological outcome (overall survival and local control) after both treatment modalities are comparable. However, no properly conducted randomized trials comparing these treatments exist. The only such trial with the endpoint of voice quality had to be prematurely closed due to low accrual.

The treatment option varies remarkably in different countries and among institutions. Especially in the case of unilateral SCCGL, other factors such as voice quality, cultural and socioeconomic factors, and patients' preference should be considered. Hoarseness is one of the main and early signs of SCCGL, whereas both radiotherapy and TLM influence voice quality by altering the vocal cord motion and anatomy. Another issue worth to consider is the treatment time. Surgery is performed in one day followed by a few days of hospital stay. In contrast, radiotherapy is applied in daily fractions. Although each fraction only takes few minutes, the patients have to visit the radiation oncology department over a course of 4 to 7 weeks, depending on the institutional preference of dose and fractionation. The post-treatment follow-up schedules are identical for both strategies.

The differences between both treatment modalities have been extensively reported. However, either due to no meaningful difference or due to the heterogeneity in the voice analysis techniques, several studies revealed no significant differences while better voice quality was reported after radiotherapy as compared with TLM in other studies.

The traditional radiotherapy involves the treatment of the whole larynx over a period of 4 to 7 weeks. Recently, a new radiotherapy technique was introduced by a team of researchers from Netherlands, where the treated target volume consists of involved vocal cord and therefore 8 to 10 fold smaller than the target volumes used for traditional whole larynx irradiation. The treatment is reduced to 16 fractions with higher dose per fraction which corresponds to 3 weeks and a day. The results of a prospective cohort (n=30) with single vocal cord irradiation (SVCI) were compared with the results of a historical prospective cohort (n=131) previously treated with whole larynx radiotherapy in the same institute. The median follow-up was 30 months. The voice handicap index (VHI) at all time points beginning from the 6th week after SVCI was significantly superior to the same time points with conventional radiotherapy. Moreover, a comparable local control with SVCI (100%) vs. conventional radiotherapy (92%) was reported at two years, p=0.2412.

In conclusion, the long-term voice quality and oncologic outcome (survival and local tumor control) are comparable with both TLM and traditional radiotherapy. Furthermore, the new SVCI technique offers a possibly superior long-term voice quality with an at least equal oncologic outcome compared to traditional radiotherapy. With this background, the investigators' main aim is to compare SVCI to TLM with the main focus of patient-reported voice quality.

Investigational Treatments and Indication

With the indication to treat early stage SCCGL in an organ preservation setting, both TLM and SVCI are going to be compared head-to-head, and therefore are considered as investigational treatments.

Clinical Evidence to Date

In well-recognized international cancer treatment guidelines, TLM and radiotherapy are considered as comparable modalities for the successful treatment of early stage SCCGL. Based on various clinical studies and meta-analyses, functional and oncological outcome (overall survival and local control) after both treatment modalities are comparable. However, no properly conducted randomized trials comparing these treatments exist. The only such trial with the endpoint of voice quality had to be prematurely closed due to low accrual.

The differences between both treatment modalities have been extensively reported. However, either due to no meaningful difference or due to the heterogeneity in the voice analysis techniques, several studies revealed no significant differences while better voice quality was reported after radiotherapy as compared with TLM in other studies. Nevertheless, most of the literature consists of reports about retrospective case series with the lack of level I evidence.

Justification of Choice of Study Population

In line with the eligibility criteria, the study population will include patients diagnosed with unilaterally situated stage 0-I SCCGL who are considered as eligible both for radiotherapy and surgery by a multidisciplinary tumor board. Both treatment modalities are well-established standards.

Study Objectives

Overall Objective The ultimate goal of the study is to compare the treatment outcome of the SVCI and TLM for unilateral stage 0-I SCCGL.

Primary Objective Comparison of patient-reported subjective voice quality after TLM and SVCI

Secondary Objectives

* Qualitative post-therapeutic comparison of the voice between study arms
* Quantitative post-therapeutic comparison of the voice between study arms
* Comparison of the oncological outcome between study arms.
* Assessment of toxicity/morbidity among study arms with the listed toxicity items provided in Appendix A. CTCAE v.5.0 will be used for the classification of toxicities.

Safety Objectives - Assessment of toxicity/morbidity among study arms with the listed toxicity items provided in Appendix A. CTCAE v.5.0 will be used for the classification of toxicities.

Study Outcomes

Primary Outcome

- Average of the VHI assessed at 6, 12, 18, and 24 months

Secondary Outcomes

* Perceptual impression of the voice via Roughness - Breathiness - Hoarseness (RBH) assessment at 6, 12, 18, and 24 months
* Quantitative characteristics of voice by means of Jitter and Shimmer (JS), Glottal-to-Noise Excitation Ratio (GNE) and Singing Power Ratio (SPR), which will be assessed at 6, 12, 18, and 24 months
* Loco-regional control of the disease at 2 and 5 years
* Treatment toxicity at 2 and 5 years based on CTCAE v.5.0

Other Outcomes of Interest The patient, disease and procedural characteristics will be described.

Safety Outcomes Although the safety endpoints within the secondary endpoints will be published only at two time points (2 and 5 years), the toxicity will be systematically assessed during and after the treatment in a more frequent schedule: during the treatment, every 3 months until 24 months, and every 6 months between the 24th and 60th months. Assessment of toxicity/morbidity among study arms with the listed toxicity items provided in Appendix A. CTCAE v.5.0 will be used for the classification of toxicities.

Study Design

General study design and justification of design This is a prospective randomized multi-center open-label comparative phase III study with a superiority design (see Section 11 for the details of statistical considerations). Primary endpoint of this study is patient-reported subjective voice quality between 6 to 24 months after randomization.

The sample size calculation is based on the primary outcome, the VHI at 6 to 24 months (averaged). Based on the literature, the investigators consider the VHI to be comparable between TLM and traditional whole larynx radiotherapy. Therefore, the working hypothesis is that there is a difference between TLM and SVCI in regard to VHI. Al-Mamgani et al. reported standard deviations for VHI ranging from 2 to 10 score points12. A difference of 8 points between the two groups are regarded as clinically relevant and a conservative standard deviation of 8 points is assumed. Based on a two-sample means test, 34 patients (17 per group) are needed to detect a difference in VHI at a two-sided alpha-level of 0.05 with a power of 80%.

This sample size calculation is conservative. In the analysis, the average difference over four time points (6, 12, 18, and 24 months) will be modelled and additionally adjusted for the baseline VHI to yield more power. In each center, patients will be enrolled into the study by the local principal investigator. The local PI can be a head and neck surgeon or radiation oncologist. However, before patient accrual, the patient must be informed about the study at least by the attending surgeon and the radiation oncologist. It is highly recommended that the patient is evaluated and informed in a multidisciplinary tumor board setting before the accrual.

Interventions in the trial are considered as non-experimental standard treatments. No diagnostic tool or imaging modality that will be used during the trial is experimental. No interim analysis for futility or safety will be performed.

Methods of minimizing bias

Randomization A probabilistic minimization technique will be used for random treatment allocation between the two treatment arms using a 1:1 ratio. The computer chooses a treatment dynamically, based on the tumor stage (Stage 0 vs. I), and VHI at baseline (\<34 vs. ≥34) as two predefined stratification factors.

Allocation will be done via a dedicated website within the clinical trial management system also containing the electronic case report forms. Only system administrators who are otherwise not involved in the trial will have access to the algorithm and stored lists during the recruitment period. Investigators receive the allocation only after registration of a patient. The underlying randomization lists and details of the minimization algorithm will not be disclosed but kept securely at CTU Bern. All these measures will help to ensure concealment of allocation.

Blinding procedures Due to obvious differences between surgery and radiotherapy, it is not possible to have a blinded design in this study setting.

The secondary phoniatric assessments will be carried out centrally by blinded phoniatricians.

VoiceS: Voice Quality After Transoral CO2-Laser Surgery Versus Single Vocal Cord Irradiation for Larynx Cancer

VoiceS: Voice Quality After Transoral CO2-Laser Surgery Versus Single Vocal Cord Irradiation for Unilateral Stage 0 & I Glottic Larynx Cancer - A Randomized Phase III Trial

After the finalization of the study, anonymized IPD will be shared upon reasonable request.

average of the VHI scores (range: 0-120) of each patient up to 24 months after randomization

The perceptual impression of a vocal signal remains the gold standard in phoniatric diagnosis. By means of reading the phonetically balanced text "The Rainbow Passage" in English and "Die Sonne und der Wind" in German, French and Italian (versions in different languages provided in the protocol), the speaking voice is assessed by the investigator according to the parameters roughness - breathiness - hoarseness (RBH), using the scale of 0: normal, 1: mild, 2: moderate, 3: severe. In this study, the assessment will be carried out blind.

JS are regarded as objective, quantitative characteristics of voice quality. They describe the variations in the fundamental note of a vocal signal. Jitter is the variation of the cycle-to-cycle frequency in held vowels (in Hz or. %, norm = 0-3%), shimmer is the cycle-to-cycle variation in the amplitude of held vowels (in dB, or. %, norm = 0-20%). In this study, the assessment will be carried out blind.

GNE serves to describe the relationship of the voice signal to the noise signal (norm = 1-0) and is also a quantitative characteristic of voice quality. Jitter, shimmer and GNE correspond to the perceptual characteristics roughness - breathiness - hoarseness. In order to carry out jitter, shimmer and GNE, the test subjects hold the vowel /a/ mezzoforte for at least 5 seconds at their average speaking pitch. The vocal samples will be recorded and subsequently evaluated using the open source freeware software Praat (http://www.fon.hum.uva.nl/praat/ by Paul Boersma and David Weenink - Phonetic Sciences, University of Amsterdam Spuistraat 210 1012VT Amsterdam, Netherlands). In this study, the assessment will be carried out blind.

The 'brilliant' sound of a voice is characterized in acoustic terms by a high degree of acoustic energy above 2 kHz. This can be calculated with the aid of the SPR. In the Fast-Fourier-Transformation, the amplitudes of the highest peaks between 2 and 4 kHz and of the highest peaks between 0 and 2 kHz are determined using a vocal sample and the one subtracted from the other. The lower the SPR, the more "sonorous" is the voice. For this, the test subjects hold the vowel /a/ mezzoforte for at least 5 seconds at their average speaking pitch. The vocal samples will be recorded and subsequently evaluated using Praat. In this study, the assessment will be carried out blind.

Event: loco-regional failure after randomization

The time-to-event outcome loco-regional control will be evaluated using Kaplan-Meier curves and a Cox model adjusted for the randomization stratification factors.

Treatment toxicity up to 5 years (based on CTCAE v.5.0) after randomization

Treatment toxicity up to 5 years will be summarized descriptively for each group, showing the overall number of events as well as number and percentage of patients with events.

Voice Handicap Index separately assessed at 6, 12, 18, and 24 months

University of Bern

The Netherlands Cancer Institute

University of Lausanne Hospitals

University Hospital, Geneva

University of Zurich

Olgun Elicin

Principal Investigator and Sponsor

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Neoplasms, Squamous Cell

François Mouawad, MD

Patients with early-stage squamous cell carcinomas of the vocal cord can be treated in an equivalent way in terms of carcinology by surgery or radiotherapy. The study will be to analyse the vocal outcome at 5 years of these two types of management in order to define whether one is superior to the other on this criterion of voice quality after treatment.

Comparison of Voice Results at 5 Years of Treatment of Glottic Squamous Cell Carcinoma T1 by Surgery Versus Radiotherapy

The VHI is a self-administered questionnaire that provides a score ranging from 0 to 120 points validated in France and internationally based on the declarative answers to 30 items of the questionnaire. A high score corresponds to a voice felt to be of poor quality. This is a subjective assessment made by the patient.

The TMP is the measurement in seconds of a vowel (/a/) held for as long as possible.

This score is obtained from an internationally and nationally validated hetero-assessment. It consists in the attribution by a listening jury made up of two people of a mark ranging from 0 to 3 for each of the 6 items: Grade, Roughness, Breathiness, Asthenia, Strain, Instability.

A high score is associated with a voice perceived as bad by the audience.

short recording of the patient's voice delivering a standardized speech on VOCALAB software validated by the scientific community.

University Hospital, Lille

Rare Diseases

Papilloma

Laryngeal Papillomatosis

Anti-Inflammatory Agents

Antirheumatic Agents

Analgesics

All Drugs and Chemicals

Celecoxib

Anti-Inflammatory Agents, Non-Steroidal

Analgesics, Non-Narcotic

Cyclooxygenase 2 Inhibitors

Cyclooxygenase Inhibitors

Enzyme Inhibitors

endoscopic treatment with once-time PDL radiation at 6.0-8.0 J on laryngeal papilloma, followed by oral taking of 9-month Celebrex (100mg, BID), in 15 subjects

once-time and routine surgery, with either of carbon dioxide (CO2) laser radiation at 10.0-20.0 W or "cold" surgery with microinstruments, in 15 subjects

oral taking of Celebrex (100 mg, BID) for 9 months

Celebrex

once time radiation on laryngeal papilloma with PDL , at 6.0-8.0 J

once-time surgery to remove laryngeal papilloma

CO2 laser or microsurgery

Wang Zhi, M.D

Respiratory recurrent papilloma (RRP) is one of the most common benign tumors. Surgical removal is the current management for RRP, but it is a very traumatic procedure, and often leads to permanent voice dysfunction. In this study, we will develop a new, combined RRP treatment with a pulsed dye laser (PDL) and Celebrex. We will determine if Celebrex, a newly developed inhibitor of cyclooxygenase (COX)-2, can provide a long-term inhibitory effect on RRP, therefore preventing RRP from recurring. This combined strategy, if successful in this proposed study, will provide a new and ideal "voice-preserving" therapy for RRP that will deliver long-term efficacy in managing RRP.

RRP and its surgeries usually involves the vocal cords or other regions of the larynx, thereby, resulting in a poor voice. Our previous studies have shown the efficacy and safety of a microvascular targeting technique (MVT) for RRP treatment using the 585 nm PDL. This technique provides a less traumatic alternative to surgery. However, postoperative recurrence of lesions still remains a problem because of microvascular regrowth. This study is a continuation of our effort to develop a new and less traumatic treatment for RRP. In this study, we will develop a new, combined RRP treatment with PDL and Celebrex. We will determine if Celebrex, a newly developed inhibitor of COX-2, can provide a long-term inhibitory effect on RRP through its anti-angiogenic activity and the synergic effect produced with the laser therapy. The hypothesis is that postoperative administration of Celebrex will provide a long-term inhibitory effect on microvascular regrowth and on COX-2 enzyme, thereby, preventing RRP from recurring after the PDL therapy. Our specific aim in this study is to determine the synergic effect between PDL and Celebrex and long-term efficacy of Celecoxib in preventing postoperative RRP recurrence. We will compare this new combined strategy with traditional treatments in 30 adult patients. This is the first time to combined this new laser MVT technique with a COX-2 inhibitor for microvascular targeting therapy of RRP. This combined strategy, if successful in this proposed study, will provide a new and ideal "voice-preserving" therapy for RRP that will deliver long-term efficacy in managing RRP and will be safe and convenient enough for use in out-patient treatment.

Celebrex (Celecoxib) Treatment of Laryngeal Papilloma

Voice-preserving Treatment of Laryngeal Papilloma

Criteria for the recurrence: the site scoring \>4, plus visible lesion found in \>50% of the treated tissue area, after surgery Description: The caculation of the site scoring is based on a called Derkay's scoring system: to indicate how many anatomic site involved, from the 0 (the best)to 13 (the worst),among a total of 13 laryngeal sites such as epiglottis or right true vocal cords.

The measuer is reported as time course (i.e., how many month) to see papilloma recurrence if there is any such recurrence.

National Institute on Deafness and Other Communication Disorders (NIDCD)

Boston University

Professor and Director

Others: laser and surgery complications for 12 months

Experiment

Control

treated with routine surgery (CO2 laser or "cold" microsurgery), in 15 cases

treated with once-time PDL, followed by oral taking of 9-month Celecoxib, in 15 cases

Experimental

Total

Age, Categorical

Sex: Female, Male

We failed to recruit a total of 30 cases, due to (1) This disease is relative less common in clinic; and (2) particularly, more and more of patients now had a serious concern in safety of Celebrex due to news and warnings to public in recent years.

Dr. Zhi Wang

treated with both of once-time PDL and 9-month Celebrex

Time Course (Month) With Papilloma Recurrence During 12-month Follow up

treated with once-time routine surgery (CO2 laser or "cold" microsurgery)

treated with once-time PDL, followed by oral taking of Celebrex (100mg,BID) for 9 months

Experienment

The paticipants for analysis were those who had the recurrence or completed follow-up period. The analysis was per protocol, and follow-up period was 12 months.

Number of Case With Papilloma Recurrence During a 12-month Follow up

once-time routine surgery with (either of CO2 laser at continue model and 10.0-20.0 W, or "cold" surgery with micro-instruments), in 15 subjects

once-time PDL surgery at 6.0-8.0 W, followed by oral taking of Celecoxib (100mg,BID)for 9 months

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
VoiceS: Voice Quality After Transoral CO2-Laser Surgery Versus Single Vocal Cord Irradiation for Larynx Cancer	NCT04057209	Glottis Tumor Larynx Cancer	Single Vocal Co... Arm A: Transora...	18 Years -	Insel Gruppe AG, University Hospital Bern
Comparison of Voice Results at 5 Years of Treatment of Glottic Squamous Cell Carcinoma T1 by Surgery Versus Radiotherapy	NCT04447456	Glottic Carcino...		18 Years -	University Hospital, Lille
Celebrex (Celecoxib) Treatment of Laryngeal Papilloma	NCT00592319	Laryngeal Papil...	Celebrex PDL CO2 laser or mi...	18 Years - 64 Years	Boston University

Spots Global Cancer Trial Database for voice

Every month we try and update this database with for voice cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for voice

Every month we try and update this database with for voice cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for voice cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.