Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Prostatic Neoplasms

Genital Neoplasms, Male

Urogenital Neoplasms

Genital Diseases

Genital Diseases, Male

Urogenital Diseases

Prostatic Diseases

Male Urogenital Diseases

Prostate cancer patients recruited from oncology clinic at Cedars-Sinai Medical Center.

Prostate cancer patients recruited from the Veteran Affairs Oncology Clinic (Durham, NC).

Continuous monitoring of physical activity including step counts, sleep, heart rate, with consumer-based wearable activity monitor (Fitbit Charge HR4 or similar model)

Wearable Activity Monitor

Gillian Gresham, PhD

Eileen Liu

Prospective observational research study to evaluate the role of wearable activity monitors to predict physical function decline among prostate cancer survivors receiving ADT.

Physical function is a known predictor of QOL in advanced prostate cancer patients and key measure of treatment tolerability. While treatment with Androgen Deprivation Therapy (ADT) improves survival, it is associated with significant toxicities that lead to physical function (PF) decline. The average age of incident prostate cancer is 66 years, and in this older group of men, chronic comorbid conditions often co-occur with diagnosis, further adding to the risk for PF decline. With over 2.9 million prostate cancer survivors in the US, there is an increasing demand for adequate symptom monitoring and PF assessment throughout cancer care. However, there are currently no validated methods to systematically evaluate and predict PF decline. Thus, the overarching objective of this proposal is to determine whether the use of wearable technology to monitor objective daily activity combined with routine symptom reporting can predict PF decline. To accomplish this, we propose a mixed-methods approach that will provide quantitative information to help identify PC survivors at higher risk for PF decline as well as a qualitative aim gain a deeper understanding of the perceived relationships that PC survivors have with their physical activity levels and treatment symptoms.

Digitally Captured Activity Data and PROs to Monitor Physical Function in Prostate Cancer Patients

Evaluating the Role of Wearable Technology and Patient-reported Outcomes to Monitor Physical Function Decline in Prostate Cancer Survivors

Patient-reported physical function defined as 5-point change in standardized NIH PROMIS t-scores (mean 50, SD: 10), where higher scores represent higher physical function)

Change will be calculated based on difference in average weekly step count at baseline from the average weekly step count at end-of-study visit as measured using a Fitbit activity monitor where mean weekly Fitbit activity values will be calculated

Change will be calculated based on difference in 24 hour activity as defined as periods of active minutes, sedentary time, and sleep at baseline and end-of-study

This is a qualitative endpoint assessed in individual patient interviews at end of study.

United States Department of Defense

Cedars-Sinai Medical Center

Assistant Professor

Respiratory Tract (Lung and Bronchial) Diseases

Carcinoma, Non-Small-Cell Lung

Lung Neoplasms

Carcinoma

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Carcinoma, Bronchogenic

Bronchial Neoplasms

4 weeks of an supervised, pre-operative exercise prescription augmented by a wearable fitness device.

Multimodal prehabilitation

Ni Zhang, Doctor

Biyun Zhou, Doctor

Wei Ping, Doctor

To explore the safety and compliance of a wearable telemedicine device that can receive basic vital signs in real time, and its active supervision mode with real-time adjustment of exercise prescription for preoperative prehabilitation exercises in patients at home; and to evaluate the effectiveness of preoperative prehabilitation exercises in a telemedicine active supervision mode in patients undergoing thoracoscopic lung tumour resection, taking into account the patient's cardiopulmonary exercise test, postoperative complications and quality of life scores.

Exercise Prehabilitation for Patients With NSCLC Before Surgery

Effect of a Home-based, Supervised Prehabilitation With Wearable Technology for Patients With Non-small Cell Lung Cancer Before Lung Resection: a Single-arm, Prospective Study

Exercise testing on a cycloergometer(VO2 max)

Forced expiratory volume in 1 s (FEV1) of pulmonary function will be measured in liters

Forced vital capacity (FVC) of pulmonary function will be measured in liters.

number of hours the fitness tracker was worn in pre-operative period

as assessed by the EORTC QLQ C30 questionnaire

Number of days from surgery to discharge home

Classified using the Clavien Dindo Classification

number of completed pre-operative exercise sessions divided by number of prescribed sessions, according to exercise log

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Digitally Captured Activity Data and PROs to Monitor Physical Function in Prostate Cancer Patients	NCT04575402	Prostate Cancer	Wearable Activi...	18 Years -	Cedars-Sinai Medical Center
Exercise Prehabilitation for Patients With NSCLC Before Surgery	NCT05608759	Prehabilitation Non Small Cell ... Cardiorespirato... Surgery	Multimodal preh...	18 Years -	Tongji Hospital

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