Neoplasms

Nervous System Diseases

Diseases and Abnormalities at or Before Birth

All Conditions

Symptoms and General Pathology

Skin and Connective Tissue Diseases

Rare Diseases

Neurofibromatoses

Neurofibromatosis 1

Neurofibroma

Nerve Sheath Neoplasms

Neoplasms, Nerve Tissue

Neoplasms by Histologic Type

Syndrome

Neoplastic Syndromes, Hereditary

Neurocutaneous Syndromes

Heredodegenerative Disorders, Nervous System

Neurodegenerative Diseases

Genetic Diseases, Inborn

Peripheral Nervous System Diseases

Neuromuscular Diseases

Nervous System Neoplasms

Peripheral Nervous System Neoplasms

Neurofibromatosis

Neurofibromatosis Type 1

Gastrointestinal Agents

All Drugs and Chemicals

Deoxycholic Acid

Injection into the cutaneous Neurofibromas lesion

Kybella

Pulse laser at a wavelength of 1064nm to the cutaneous Neurofibromas lesion

1064nm laser

Pulse laser at a wavelength of 755nm to the cutaneous Neurofibromas lesion

755nm Alexandrite Laser

R. Rox Anderson, MD

This study will evaluate the tolerability and effectiveness of three FDA-approved treatments in Neurofibromatosis Type 1 Cutaneous Neurofibromas. These treatments are: a 1064nm laser, a 755nm laser, and a Kybella injection. Each patient will have a treatment and a control site.

Tolerability of Device Based Therapies for Neurofibromatosis Type 1 Cutaneous Neurofibromas

Device based treatment will be considered tolerable if \<40% of participants treated have a \>grade 2 adverse event (AE). A grade 2 AE is defined as an event that requires treatment.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Tolerability of Device Based Therapies for Neurofibromatosis Type 1 Cutaneous Neurofibromas	NCT04730583	Cutaneous Neuro...	Kybella 1064nm laser 755nm Alexandri...	18 Years - 85 Years	Massachusetts General Hospital
Tolerability of Device Based Therapies for Neurofibromatosis Type 1 Cutaneous Neurofibromas	NCT04730583	Cutaneous Neuro...	Kybella 1064nm laser 755nm Alexandri...	18 Years - 85 Years	Massachusetts General Hospital

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