Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Respiratory Tract (Lung and Bronchial) Diseases

Infections

Wounds and Injuries

Symptoms and General Pathology

Breast Neoplasms

Lung Neoplasms

Pneumonia

Radiation Pneumonitis

Communicable Diseases

Respiratory Tract Infections

Lung Diseases

Respiratory Tract Diseases

Lung Diseases, Interstitial

Lung Injury

Radiation Injuries

High fidelity functional lung imaging (HFFLI) is an improved method of measuring pulmonary function by analyzing 3-Dimensional (3D) motion. Using this technique, we are able to detect and localize pathological changes in the lung with sub-segmental resolution. The approach uses a unique cross-correlation analysis and non-linear optimization to reconstruct lung tissue motion from a small number of standard projections. All participants will undergo standard 4D Computed Tomography (CT), standard Cone Beam CT, research Low-dose Cinefluorography, and additional research Pulmonary Function Tests.

The initial 4DCT imaging obtained as part of a subject's planning CT for their standard radiation treatment.

4D Computed Tomography (CT)

Daily cone beam CT imaging at each radiation treatment visit, as part of standard care

Cone Beam CT

A series of images consisting of five six-second cinefluorographs (real time fluoroscopic movies, for a total each time of 30 seconds of fluoroscopy) of the lungs while the subject is breathing, each at precisely measured angles to the subject, on 4 different occasions.

Low-dose Cinefluorography

Pulmonary Function Testing (PFT) gives global functional data for the lungs as a whole, but is relatively insensitive to early pathological changes. It involves taking very deep breaths and exhaling as forcefully as possible.

Research PFTs will be conducted at 4 and 12-months post radiation therapy

Pulmonary Function Tests

Stephen Shiao

Karen Kearns

Stephen Shiao, MD, PhD

The purpose of this study is to to compare lung function data generated by applying High Fidelity Functional Lung Imaging (HFFLI) software to 4D CT, cone beam CT, and fluoroscopic images of the lungs breathing to determine whether different modalities of imaging provide similar data on lung movement and function. HFFLI may detect changes in lung function in patients undergoing External Beam Radiotherapy for cancer.

This study is designed to test a novel technology to examine early changes in the lung in hopes of identifying patients who may be at risk for radiation pneumonitis. Eligible subjects will undergo standard of care treatment with the use of the Varian TrueBeam system for radiation therapy of a cancer lesion in the chest. The imaging data acquired as part of usual standard of care for these patients is a pre-treatment 4D planning CT scan, and a daily cone beam CT at each radiation treatment visit. We will also obtain a series of images consisting of five six-second cinefluorographs (real time fluoroscopic movies, for a total each time of 30 seconds of fluoroscopy) of the lungs while the subject is breathing, each at precisely measured angles to the subject, on 4 different occasions. This study will compare lung function data generated by applying High Fidelity Functional Lung Imaging (HFFLI) software to 4D CT, cone beam CT, and fluoroscopic images of the lungs breathing to determine the degree of correlation between data generated from different imaging modalities. The study is open to adults over the age of 18, at any stage of cancer.

Novel Lung Imaging in Adults Undergoing Radiation Therapy to Assess for Radiation Pneumonitis

Novel High Fidelity Functional Lung Imaging in Adults Undergoing Radiation Therapy to Assess for Radiation Pneumonitis

As part of standard care, patients will have a cone beam CT on each day they receive radiation treatment. Treatment period varies.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Novel Lung Imaging in Adults Undergoing Radiation Therapy to Assess for Radiation Pneumonitis	NCT02735746	Lung Cancer Breast Cancer Mediastinum Les... Radiation Pneum...	4D Computed Tom... Cone Beam CT Low-dose Cinefl... Pulmonary Funct...	18 Years -	Cedars-Sinai Medical Center
Novel Lung Imaging in Adults Undergoing Radiation Therapy to Assess for Radiation Pneumonitis	NCT02735746	Lung Cancer Breast Cancer Mediastinum Les... Radiation Pneum...	4D Computed Tom... Cone Beam CT Low-dose Cinefl... Pulmonary Funct...	18 Years -	Cedars-Sinai Medical Center
Novel Lung Imaging in Adults Undergoing Radiation Therapy to Assess for Radiation Pneumonitis	NCT02735746	Lung Cancer Breast Cancer Mediastinum Les... Radiation Pneum...	4D Computed Tom... Cone Beam CT Low-dose Cinefl... Pulmonary Funct...	18 Years -	Cedars-Sinai Medical Center

Spots Global Cancer Trial Database for 4d computed tomography (ct)