Neoplasms

Blood and Lymph Conditions

All Conditions

Immune System Diseases

Rare Diseases

Leukemia

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Leukemia, Lymphoid

Acute Lymphoblastic Leukemia

Lymphoblastic Lymphoma

Acute Graft Versus Host Disease

Childhood Acute Lymphoblastic Leukemia

Antineoplastic Agents

Antirheumatic Agents

Dermatologic Agents

Reproductive Control Agents

All Drugs and Chemicals

Methotrexate

The group of patients which are treated with 3g/m2 MTX, low risk ALL or NHL

3g MTX

The group of patients which are treated with 5g/m2 MTX, they are high or middle risk ALL patients

5g MTX

Weiqun Xu

\* The pharmacokinetics of MTX were assessed with regards to the relevance of several different patient specific factors in 291 pediatric patients, who were administered with high dose of MTX. Population pharmacokinetics of MTX analysis was performed by using nonlinear mixed effects modeling.

* Methotrexate (MTX) is one of the critical components for treating all forms of acute lymphoblastic leukemia (ALL), which is the most common pediatric cancer. Unfortunately, high dose MTX has several undesirable side effects and MTX toxicity vastly differs from patient to patient.
* The pharmacokinetics of MTX were assessed with regards to the relevance of several different patient specific factors in 291 pediatric patients, who were administered with high dose of MTX. Population pharmacokinetics of MTX analysis was performed by using nonlinear mixed effects modeling.
* The final model was validated using nonparametric bootstrap analysis. Body surface area (BSA), pre-hydration, baseline serum creatinine and 24 h creatinine clearance rate were statistically significant covariates for distributional volume (V) and renal clearance (CL). Herein, is the first report of analysis of the importance of a series of patient factors on pharmacokinetics of MTX by one-compartment model. Using these data, we have established an efficient population pharmacokinetic model for MTX, which can be used to predict safe clinical application of MTX especially in children with ALL.

Pharmacokinetic Analysis of High Dose Methotrexate in Pediatric Lymphoblastic Malignancies

Pharmacokinetic Analysis of High Dose Methotrexate in Pediatric Acute Lymphoblastic Leukemia: Significant Impact Factors and Establishment of a Clinically Relevant Model

The serum MTX is higher than 1umol/L in 48 hours or 0.1umol/L in 96 hours

The Children's Hospital of Zhejiang University School of Medicine

Doctor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Pharmacokinetic Analysis of High Dose Methotrexate in Pediatric Lymphoblastic Malignancies	NCT02011022	Methotrexate Ad...	3g MTX 5g MTX	- 18 Years	The Children's Hospital of Zhejiang University School of Medicine
Pharmacokinetic Analysis of High Dose Methotrexate in Pediatric Lymphoblastic Malignancies	NCT02011022	Methotrexate Ad...	3g MTX 5g MTX	- 18 Years	The Children's Hospital of Zhejiang University School of Medicine
Pharmacokinetic Analysis of High Dose Methotrexate in Pediatric Lymphoblastic Malignancies	NCT02011022	Methotrexate Ad...	3g MTX 5g MTX	- 18 Years	The Children's Hospital of Zhejiang University School of Medicine

Spots Global Cancer Trial Database for 5g mtx

Every month we try and update this database with for 5g mtx cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for 5g mtx

Every month we try and update this database with for 5g mtx cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for 5g mtx cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.