Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Symptoms and General Pathology

Nervous System Diseases

Rare Diseases

Breast Neoplasms

Chronic Pain

Pain

Acute Pain

Neurologic Manifestations

Chronic Graft Versus Host Disease

Acute Graft Versus Host Disease

Central Nervous System Depressants

All Drugs and Chemicals

Anesthetics

PECS II or ESP block are performed 30 minutes before general anesthesia. PCA is used for all the patients in the first 24 hours postoperatively.

In the control group, patients will have only general anesthesia. PCA is used for all the patients in the first 24 hours postoperatively.

PECS II block will be performed 30 min. before general anesthesia.

Pectoralis nerve block II

ESP block will be performed 30 minutes before general anesthesia.

Erector spine plane block

Only general anesthesia will be performed.

Control

CENGİZ KAYA, MD

This study evaluates the analgesic effects of pectoralis nerve block (PECS II) and erector spinae plane block (ESP) in patients having segmental mastectomy and sentinel lymph node biopsy (SLNB). Each one-third of patients will have ESP block and pectoralis nerve block (PECS II) 30 min before general anesthesia , while other one-third of patients will have only general anesthesia.

It has been proven that PECS II and ESP both supply effective analgesia in the first 24 hours after mastectomy. But they do so by different mechanishms.

This study is to survey that ESP and PECS II may supply acute and chronic analgesia by reducing pain scores in the first 24 hours and 3 months after the surgery, also the comparison of the analgesic activity among themselves for acute / chronic pain and opioid consumption will be searched.

In this study patients are divided into three groups. Patients in PECS group will have PECS II block in a separate section from the operating rooms (PNB practice room). In addition, patient controlled analgesia (PCA) will be used in the first 24 hours postoperatively.

Patients in ESP group will have ESP block in a separate section from the operating rooms (PNB practice room). In addition, PCA will be used in the first 24 hours postoperatively.

Patients in control group will not be performed nerve block. Only general anesthesia (GA) will be performed in the operation room. In addition, PCA will be used in the first 24 hours postoperatively.

Randomization of the study will be done by a doctor who will not participate in patient follow-up with closed envelopes using computer generated generated random numbers.

The anesthesia doctor who will perform the peripheral nerve block will be informed with a sealed envelope by an independent assistant outside the study.

Women with breast cancer having segmental mastectomy and sentinel lymph node biopsy (SLNB)

Pectoral Nerve Block II and Erector Spine Plane Block in Breast Cancer Surgery

Research of the Effects of Pectoralis Nerve Block II and Erector Spina Plan Block in Breast Cancer Surgery

The time of first analgesic demand was defined as the time to first PCA bolus after patient PACU arrival.

Morphine consumption in the first 24 hours will be counted by IV PCA. Patients will be able to request opioids via PCA device when the vas score is 4 points or more when the arm is in the resting position.

Pain status will be evaluated based on VAS scores in two different positions: arm at rest and arm in abduction. Pain status will be evaluated at 1-3-6-12-24. hours after surgery. Each VAS is scores 0-10. (0=no pain ; 10=pain as bad as can be)

Following induction of general anesthesia, anesthesia maintenance will be continued with sevoflurane to BIS 40-60 (bispectral index). When the BIS is between 40-60, remifentanil infusion rate will be changed considering ± 20% changes in blood pressure compared to baseline values.The total amount of remifentanil consumed will be recorded.

The patients will be evaluated according to the five-stage verbal descriptive PONV scale. If it is 3 points or more, ondansetron 4 mg IV will be administered. Wait for 8 hours for the next dose of ondansetron. (0 = None, 1 = Slight nausea, 2 = Moderate nausea, 3 = Once vomiting, 4 = vomiting more than one)

The number of patient requires rescue analgesic will be recorded at 1-3-6-12-24. hours after surgery

Pain status will be evaluated in the third month after surgery based on VAS scores in two different positions: arm at rest and arm in abduction. Each VAS is scores 0-10. (0=no pain ; 10=pain as bad as can be)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Pectoral Nerve Block II and Erector Spine Plane Block in Breast Cancer Surgery	NCT04135157	Anesthesia Analgesia Acute Pain Chronic Pain Pectoralis Nerv... Erector Spine P... Patient Control...	Pectoralis nerv... Erector spine p... Control	18 Years - 65 Years	Ondokuz Mayıs University
Pectoral Nerve Block II and Erector Spine Plane Block in Breast Cancer Surgery	NCT04135157	Anesthesia Analgesia Acute Pain Chronic Pain Pectoralis Nerv... Erector Spine P... Patient Control...	Pectoralis nerv... Erector spine p... Control	18 Years - 65 Years	Ondokuz Mayıs University

Spots Global Cancer Trial Database for acute and chronical pain