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laparoscopy-assisted distal gastrectomy

open distal gastrectomy

Hyung-Ho Kim, MD, PhD

Chan Young Kim, MD

Sang Il Lee, MD

Sang IL Lee, MD

Gyu Seok Cho, MD, PhD

Wook Kim, MD, PhD

Seung-Wan Ryu, MD, PhD

Min Chan Kim, MD, PhD

Do Joong Park, MD

Hyuk-Joon Lee, MD, PhD

Han Kwang Yang, MD, PhD

Woo Jin Hyung, MD, PhD

Kyo Young Song, MD, PhD

Joo Ho Lee, MD

Seung Ho Choi, MD

Tae Sung Sohn, MD

Sang-Uk Han, MD, PhD

Hyung Min Jin, MD

Kyu Yeol Kim, MD

The purpose of this study is to assess the usefulness of laparoscopic surgery for gastric cancer in comparison with open gastrectomy.

Recently, in technical aspects, almost all kinds of open gastric cancer surgeries can be reproduced laparoscopically. However, many controversies exist due to no evidence and no long-term results. There was no prospective multi-center large-scale randomized controlled trial in the world on the long-term outcome of laparoscopic gastric cancer surgery.

Korean Laparoscopic Gastrointestinal Surgery Study Group, therefore, proposed a multi-institutional prospective randomized trial on comparing laparoscopy-assisted versus open distal gastrectomy for gastric cancer (KLASS Trial) after the feasibility and validity of these procedures had been evaluated by analyzing retrospective multi-center large series.

This KLASS trial is supported by a grant for 2005 from the National R\&D Program for Cancer Control, Ministry of Health \& Welfare, Republic of Korea. Nine surgeons from 9 centers are participating in this trial. All the participants performed more than 50 cases of open and laparoscopic gastrectomies, respectively and their institutes had more than 80 cases of gastric cancer surgeries per year. Primary endpoint of this trial is to elucidate that there is no difference of overall and disease-free survivals between laparoscopic and open groups. The KLASS trial consists of 5 major subjects: comparison of 5-year overall and disease-free survivals, standardization of preoperative diagnosis, assessment of the quality of life, evaluation of postoperative inflammatory response and immune function, and cost-effectiveness. The KLASS trial will be able to validate and verify laparoscopic gastric cancer surgery.

Comparison of Laparoscopic Versus Open Gastrectomy for Gastric Cancer: A Prospective Randomized Trial

Multi-institutional Prospective Randomized Trial on the Assessment of Laparoscopic Surgery for Gastric Cancer

National Cancer Center, Korea

Minimally invasive surgery revolutionized the field of gastric cancer surgery. The surgical robot was introduced to alleviate the difficulty of laparoscopic surgery. Although many studies have reported successful outcomes for robotic surgery, there is no multicenter prospective analysis regarding the advantage of the robotic gastrectomy. The aim of this study is to analyze the surgical outcomes of the robotic gastrectomy focusing on the learning curve, cost-effectiveness, quality of life, and acute-inflammatory reaction in comparison with laparoscopic gastrectomy.

Multi-institutional Study on the Assessment of Robotic Surgery for Gastric Cancer

Yonsei University

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Comparison of Laparoscopic Versus Open Gastrectomy for Gastric Cancer: A Prospective Randomized Trial	NCT00452751	Gastric Cancer	laparoscopy-ass... open distal gas...	20 Years - 80 Years	National Cancer Center, Korea
Multi-institutional Study on the Assessment of Robotic Surgery for Gastric Cancer	NCT01309256	Gastric Cancer		20 Years -	Yonsei University
Comparison of Laparoscopic Versus Open Gastrectomy for Gastric Cancer: A Prospective Randomized Trial	NCT00452751	Gastric Cancer	laparoscopy-ass... open distal gas...	20 Years - 80 Years	National Cancer Center, Korea

Spots Global Cancer Trial Database for acute inflammatory reaction