Spots Global Cancer Trial Database for Comparison of Laparoscopic Versus Open Gastrectomy for Gastric Cancer: A Prospective Randomized Trial
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Trial Identification
Brief Title: Comparison of Laparoscopic Versus Open Gastrectomy for Gastric Cancer: A Prospective Randomized Trial
Official Title: Multi-institutional Prospective Randomized Trial on the Assessment of Laparoscopic Surgery for Gastric Cancer
Study ID: NCT00452751
Conditions
Study Description
Brief Summary: The purpose of this study is to assess the usefulness of laparoscopic surgery for gastric cancer in comparison with open gastrectomy.
Detailed Description: Recently, in technical aspects, almost all kinds of open gastric cancer surgeries can be reproduced laparoscopically. However, many controversies exist due to no evidence and no long-term results. There was no prospective multi-center large-scale randomized controlled trial in the world on the long-term outcome of laparoscopic gastric cancer surgery. Korean Laparoscopic Gastrointestinal Surgery Study Group, therefore, proposed a multi-institutional prospective randomized trial on comparing laparoscopy-assisted versus open distal gastrectomy for gastric cancer (KLASS Trial) after the feasibility and validity of these procedures had been evaluated by analyzing retrospective multi-center large series. This KLASS trial is supported by a grant for 2005 from the National R\&D Program for Cancer Control, Ministry of Health \& Welfare, Republic of Korea. Nine surgeons from 9 centers are participating in this trial. All the participants performed more than 50 cases of open and laparoscopic gastrectomies, respectively and their institutes had more than 80 cases of gastric cancer surgeries per year. Primary endpoint of this trial is to elucidate that there is no difference of overall and disease-free survivals between laparoscopic and open groups. The KLASS trial consists of 5 major subjects: comparison of 5-year overall and disease-free survivals, standardization of preoperative diagnosis, assessment of the quality of life, evaluation of postoperative inflammatory response and immune function, and cost-effectiveness. The KLASS trial will be able to validate and verify laparoscopic gastric cancer surgery.
Eligibility
Minimum Age: 20 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Chonbuk National University Hospital, Chonjoo, Chonbuk, Korea, Republic of
Chungnam National University Hospital, Daejun, Chungnam, Korea, Republic of
Soonchunhyang University College of Medicine, Bucheon, , Korea, Republic of
Catholic University Holy Family Hospital, Bucheon, , Korea, Republic of
Keimyung University College of Medicine, Daegu, , Korea, Republic of
Dong-A University College of Medicine, Pusan, , Korea, Republic of
Seoul National University Bundang Hospital, Seongnam, , Korea, Republic of
Seoul National University Hospital, Seoul, , Korea, Republic of
Yonsei University College of Medicine, Seoul, , Korea, Republic of
Catholic University Kangnam St. Mary's Hospital, Seoul, , Korea, Republic of
Ewha Womans University Hospital, Seoul, , Korea, Republic of
Kangnam Severance Hospital, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
Ajou University College of Medicine, Suwon, , Korea, Republic of
St. Vincent's Hospital, Suwon, , Korea, Republic of
Ulsan University Hospital, Ulsan, , Korea, Republic of
Contact Details
Name: Hyung-Ho Kim, MD, PhD
Affiliation: Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Korea
Role: PRINCIPAL_INVESTIGATOR
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