Symptoms and General Pathology

All Conditions

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Inflammation

Prostatic Neoplasms

Genital Neoplasms, Male

Urogenital Neoplasms

Genital Diseases

Genital Diseases, Male

Urogenital Diseases

Prostatic Diseases

Male Urogenital Diseases

Tanja Langsenlehner

Previous studies have reported that cancer survivors develop age-related chronic conditions like frailty, sarcopenia, cardiac dysfunction, and cognitive impairment earlier and/or at a greater burden than similarly aged individuals never diagnosed with cancer or exposed to cancer therapies.

However, the knowledge about aging-associated consequences of cancer treatment and the processes that underlie differential responses to therapy is very limited. In 2018, a think tank established by the National Cancer Institute has defined various research needs to expand the evidence base for aging-related consequences of cancer treatment, such as studies to examine aging-related processes that include regularly performed assessments capturing factors associated with physical function or studies to elucidate pathways that lead to the emergence of aging phenotypes and to understand the relationships between biomarkers of aging and functional outcomes in cancer survivors. In addition, study inclusion of older adults with comorbidities and higher levels of frailty has been proposed to achieve an improved understanding of functional outcomes at any age.

Hypotheses / objectives We hypothesize that prostate cancer radiotherapy accelerates aging-related processes, furthermore, aging-related biomarkers may predict functional outcomes and represent early indicators of aging phenotypes. Primary objectives of the proposed study are the determination of the aging-related consequences of radiotherapy in prostate cancer patients and the evaluation of the relationship between biomarkers of aging and age-related clinical conditions.

Systematic evaluations of functional and cognitive status, comorbidities, health status, mobility, nutritional status, psychological status, and social circumstances as well as measurements of cellular senescence and chronic inflammation will be performed in a cohort of prostate cancer patients at baseline (before radiotherapy), at the end of radiotherapy and at follow-up intervals thereafter. The evaluation of aging-related biomarkers will include determination of markers of cellular senescence and markers of systemic inflammation. The correlation between genetic variants modulating telomere length and the risk of developing age-related phenotypes will also be analyzed.

Influence of Prostate Cancer Radiation on Aging

Influence of Radiotherapy on the Dynamics of Aging in Prostate Cancer Patients

In is not planned to make individual participant data (IPD) available to other researchers.

Functional decline measured by Activities of Daily Living examination (range, 0-6; high values indicate high functionality and improved outcome)

Functional decline measured by the Instrumental Activities of Daily Living examination (range, 0-8; high values indicate high functionality and improved outcome)

Cognitive disorder measured by the Mini-Mental State Examination (range, 0-30; high values indicate normal cognition and improved outcome)

Comorbidities measured by the Charlson comorbidity index (range, 0-37; high score indicates high rate of comorbidities and worse outcome)

Mental disorder measured by the Geriatric depression scale (range, 0-30; higher values indicate depression and worse outcome)

Mobility measured by the Timed up and go test (≥12 seconds to complete the Timed up and go test indicates mobility impairment and worse outcome)

Polypharmacy represents an aging related condition (high number of medication taken indicates worse outcome)

Study title	NCT ID	Conditions	Eligibility	Organization
Influence of Prostate Cancer Radiation on Aging	NCT04321187	Prostate Cancer Aging Disorder Radiotherapy; C... Inflammation	70 Years - 100 Years	Medical University of Graz
Influence of Prostate Cancer Radiation on Aging	NCT04321187	Prostate Cancer Aging Disorder Radiotherapy; C... Inflammation	70 Years - 100 Years	Medical University of Graz
Influence of Prostate Cancer Radiation on Aging	NCT04321187	Prostate Cancer Aging Disorder Radiotherapy; C... Inflammation	70 Years - 100 Years	Medical University of Graz

Spots Global Cancer Trial Database for aging disorder