Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Lung Neoplasms

Carcinoma, Non-Small-Cell Lung

Carcinoma

Carcinoma, Squamous Cell

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Neoplasms, Squamous Cell

Carcinoma, Bronchogenic

Bronchial Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Antineoplastic Agents

All Drugs and Chemicals

Gemcitabine

Paclitaxel

Carboplatin

Albumin-Bound Paclitaxel

Tubulin Modulators

Antimitotic Agents

Antimetabolites

Treatment of Albumin paclitaxel plus carboplatin

Treatment of Gemcitabine plus carboplatin

Patients receive carboplatin AUC=5 q3w and nab-p 135 mg/m2 weekly for 2 weeks (on days 1 and 8 of a 21-day cycle), followed by a week of rest.

Albumin paclitaxel plus carboplatin

Patients receive carboplatin AUC=5 q3w and gemcitabine 1250 mg/m2 weekly for 2 weeks (on days 1 and 8 of a 21-day cycle), followed by a week of rest.

Gemcitabine plus carboplatin

Wu Yilong, professor

This trial is to study the efficacy of nab-PC vs. GC and evaluate toxicity of nab-PC in advanced squamous cell cancer of lung. The correlation between the efficacy of nab-PC and some biomarkers is also to be evaluated.

Albumin-bound paclitaxel(nab-P) utilizes the albumin binding proteins,such as (gp60)/caveolin-1 (CAV1) and SPARC(secreted protein acidic and rich in cysteine), achieving high intratumoral paclitaxel accumulation. It is reported that CAV1 is overexpressed in squamous cell cancer(SQC), so it is possible that nab-PC is more highly active than GC in SQC of lung.

Nab-Paclitaxel Treatment in Advanced Squamous Cell Carcinoma of Lung

A Randomized Phase II Clinical Trial of Nab-Paclitaxel and Carboplatin Compared With Gemcitabine and Carboplatin as First-line Therapy in Advanced Squamous Cell Carcinoma of Lung

ORR is evaluated after at most 6 cycles of chemotherapy, which may cost 18 weeks.

Chinese Society of Lung Cancer

Professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Nab-Paclitaxel Treatment in Advanced Squamous Cell Carcinoma of Lung	NCT01236716	Carcinoma, Non-...	Albumin paclita... Gemcitabine plu...	18 Years - 85 Years	Chinese Society of Lung Cancer
Nab-Paclitaxel Treatment in Advanced Squamous Cell Carcinoma of Lung	NCT01236716	Carcinoma, Non-...	Albumin paclita... Gemcitabine plu...	18 Years - 85 Years	Chinese Society of Lung Cancer

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