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Antineoplastic Agents

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All Drugs and Chemicals

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Central Nervous System Depressants

Other Dietary Supplements

Cyclophosphamide

Fludarabine

Fludarabine phosphate

Mycophenolic Acid

Sirolimus

Benzocaine

Allopurinol

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Antitubercular Agents

Enzyme Inhibitors

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Tannic Acid

On day 0, a target dose of 5 x 106 CD34 cells/kg will be infused.

Peripheral Blood Stem Cell Transplant

300 mg/day from day -7 to day 0. Allopurinol 150mg/m2/day for pediatric participants.

Allopurinol 300 MG

30 mg/m2 IV over 1 hour. Administered on day -6 to day -2.

Administered as a 2 hour IV infusion on day -6, +3, and +4.

On day 0, a target dose of 3 x 108 nucleated cells/kg recipient weight will be infused.

Bone Marrow Cell Transplant

The dose of TBI will be 200 cGy given in a single fraction on day -1.

Total Body Irradiation

All participants begin +5 to day +100.

Loading dose on day +5 of 5 mg/m2/day orally once (max dose of 8 mg).

Maintenance dose 2.5 mg/m2 orally daily to maintain a level of 8-12 ng/ml (max dose of 4 mg).

Sirolimus Pill

All patients begin day +5 through day +35.

3 gram/day IV/PO for patients who are ≥ 40 kg divided in 2 doses. In obese patients (\>125% IBW) 15 mg/kg every 12 hours may be considered. Pediatric patients will receive MMF at the dose of 15 mg/kg/dose (maximum of 1 gram per dose) every 8 hours.

Mycophenolate Mofetil

Mark Juckett

This is a Phase II study following subjects proceeding with our Institutional non-myeloablative cyclophosphamide/ fludarabine/total body irradiation (TBI) preparative regimen followed by a related, unrelated, or partially matched family donor stem cell infusion using post-transplant cyclophosphamide (PTCy), sirolimus and MMF GVHD prophylaxis.

Allo HSCT Using RIC and PTCy for Hematological Diseases

Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced Intensity Conditioning (RIC) With Post-Transplant Cytoxan (PTCy) for the Treatment of Hematological Diseases

Number of participants with GVHD grades 2-4 after one year post transplant.

Number of participants with chronic GVHD after one year post transplant.

Number of participants that experienced relapse within 100 days of treatment.

Observe overall participant survival at Day 100 and at 1 and 3 years

Number of participants with transplant related mortality within 12 months of treatment.

Masonic Cancer Center, University of Minnesota

Spots Global Cancer Trial Database for allopurinol 300 mg