Neoplasms

Digestive System Diseases

Gland and Hormone Related Diseases

All Conditions

Symptoms and General Pathology

Rare Diseases

Pancreatic Neoplasms

Postoperative Complications

Pancreatic Diseases

Gastrointestinal Neoplasms

Digestive System Neoplasms

Endocrine Gland Neoplasms

Gastrointestinal Diseases

Endocrine System Diseases

Pancreatic Cancer

Ropivacain-infusion 2 mg/ml 1,25ml/h/10kg IBW (ideal body weight) is started to patients in the beginning of the surgery and is continued to POD 4. The rest of the treatment obey study protocol in both groups.

Analgesia via epidural catheter

Ropivacain 5 mg/ml 2,5ml/10kg IBW (ideal body weight) is given to patients in the end of the surgery. After that ropivacain-infusion 2mg/ml 1,25ml/h/10kg IBW is started to patients and is continued to POD 4. The rest of the treatment obey study protocol in both groups.

Analgesia via wound catheter

Piia Peltoniemi, M.D.

Pertti Pere, Ass.Prof

Pertti Pere, M.D, docent

Hanna Seppänen, Ass.Prof

Teija Nieminen, M.D

Arto Kokkola, Ass.Prof

The study is a randomised controlled trial comparing the effectivity and impact of epidural analgesia and wound catheter analgesia in patients undergoing pancreaticoduodenectomy. The aim of the study is to examine whether there are a difference in perioperative fluid therapy and complication rates between the patients in epidural and wound catheter groups.

All patients undergoing pancreaticoduodenectomy in Helsinki University Hospital are recruited in the study. Patients meeting the inclusion criteria and giving consent to participate the study will be randomised to whether epidural analgesia group or wound catheter analgesia group. Both groups get additional analgesia with intravenous PCA-oxycodone (patient controlled analgesia).

Improvement of Care of Patients Undergoing Pancreaticoduodenectomy

The amount of fluid (crystalloids and albumin) patients have got during the surgery and postoperatively (ml/kg).

The amount of norepinephrine patients have got intraoperatively and postoperatively (mg/kg).

The amount of oxycodone patients have dosed via i.v. PCA pump (mg).

Clavien-Dindo complications (scale 0-5), pancreatic fistulas (ISGPF definition, grade A-C), postpancreatectomy hemorrage (IPGPS definition, grade A-C), delayed gastric emptying (ISGPS definition, grade A-C).

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Improvement of Care of Patients Undergoing Pancreaticoduodenectomy	NCT04668781	Pancreatic Dise... Pancreas Cancer	Analgesia via e... Analgesia via w...	18 Years - 90 Years	Helsinki University Central Hospital
Improvement of Care of Patients Undergoing Pancreaticoduodenectomy	NCT04668781	Pancreatic Dise... Pancreas Cancer	Analgesia via e... Analgesia via w...	18 Years - 90 Years	Helsinki University Central Hospital

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