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anatomical liver resection by means of IOUS-finger compression

anatomical liver resection

Non-anatomical liver resection

Guido Torzilli, MD, PhD

Whether anatomical is better than non anatomical resection for HCC is still debated. This prospective randomized study aimed to address which approach is better in terms of patients prognosis.

Prognostic Impact of Anatomical Resection Vs. Non-anatomical Resection for HCC

Anatomical Liver Resection by Means of Ultrasound-guided Vessel Compression Versus Non-anatomical Resection for Hepatocellular Carcinoma: A Randomized Controlled Trial

University of Milan

resect the tumor located liver segment or lobe

non-anatomical liver resection, but insure adequate resection margin

Liver resection is performed to achieve R0 resection for patients with appropriate BCLC staging, indocyanine green retention rate, Child-pugh grading and adequate liver remnant.

Binhao Zhang, M.D.

Xiaoping Chen, M.D.

Anatomical liver resection was widely accepted as first line curative therapy for hepatocellular carcinoma. However, number of retrospective clinical studies showed no priority of anatomical resection for hepatocellular, compared with non-anatomical resection.

Surgical resection margin is a essential factor that may affect tumor prognosis. It is controversial whether adequate liver resection margin is associated with improved survival outcome in patients with hepatocellular.

There was few prospective clinical trial to investigate whether anatomical liver resection is superior to non-anatomical resection or liver resection with adequate margin is superior to that with inadequate margin. This prospective clinical trial aims at fix these issues.

In the anatomical liver resection group, liver segmentectomy or lobectomy is performed to insure curative resection (R0 resection). The region of liver resected is based on the anatomy or portal vein and hepatic vein. The liver pedicle of the tumor located lobe is exposed and dissected, which is principle to perform anatomical liver resection.

In the non-anatomical liver resection group, the liver parenchyma transection is around 0-2 cm from the tumor margin, according to tumor size and location.

Anatomy-based Resection or Margin-based Resection for Hepatocellular Carcinoma

Anatomy-based Resection or Margin-based Resection for Hepatocellular Carcinoma: A Randomized Controlled Trial

time duration of liver parenchyma transection

millilitre of blood lost during operation

3 year and 5 year overall survival and disease free survival

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Prognostic Impact of Anatomical Resection Vs. Non-anatomical Resection for HCC	NCT01236989	Patients Affect... Disease-Free Su... Overall Surviva...	anatomical live... Non-anatomical ...	-	University of Milan
Anatomy-based Resection or Margin-based Resection for Hepatocellular Carcinoma	NCT03652896	Hepatocellular ...	anatomical live...	17 Years - 65 Years	Huazhong University of Science and Technology
Prognostic Impact of Anatomical Resection Vs. Non-anatomical Resection for HCC	NCT01236989	Patients Affect... Disease-Free Su... Overall Surviva...	anatomical live... Non-anatomical ...	-	University of Milan
Anatomy-based Resection or Margin-based Resection for Hepatocellular Carcinoma	NCT03652896	Hepatocellular ...	anatomical live...	17 Years - 65 Years	Huazhong University of Science and Technology

Spots Global Cancer Trial Database for anatomical liver resection