Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Breast Neoplasms

Breast Diseases

Skin Diseases

Central Nervous System Depressants

All Drugs and Chemicals

Analgesics

Anesthetics

Propofol

Remifentanil

Hypnotics and Sedatives

Anesthetics, Intravenous

Anesthetics, General

Analgesics, Opioid

Narcotics

participants receive total intravenous anesthesia with remifentanil-propofol mixture by single TCI pump infusion

participants receive total intravenous anesthesia with remifentanil and propofol separately by two TCI pumps infusion

Participants receive total intravenous anesthesia with remifentanil-propofol mixture by single TCI pump in intervention group. All TCI target concentration adjustments or extra bolus of propofol or remifentanil during operation were based on BIS and ANI monitor.

Remifentanil-propofol mixture

Zhi-Fu Wu, M.D.

Co-administration of propofol and remifentanil is considered to be an ideal total intravenous anesthesia technique, which is widely used in induction and maintenance of general anesthesia. Remifentanil and propofol can be mixed in polypropylene syringes for one hour with a remaining concentration of 91% in small concentrations of remifentanil. However, delivery of remifentanil-propofol mixture by target-controlled infusion(TCI) for general anesthesia in surgical procedure has not been described. Breast cancer surgery ( including modified radical mastectomy and breast-conserving surgery) is a less time-consuming procedure for patients with breast cancer with one-hour duration in our hospital. This pilot study was to examine the merit of remifentanil-propofol mixture as a GA regimen for breast cancer surgery.

Previous studies has described the feasibility and safety of remifentanil-propofol mixture use in sedation of pediatric patients undergoing magnetic resonance imaging or flexible fiberoptic bronchoscopy.

84 patients scheduled for breast cancer surgery were randomly allocated to receive TIVA with propofol and remifentanil separately by two TCI pump (Separate group) or with remifentanil-propofol mixture by single TCI pump (Mix group), all TCI concentration adjustments during operation were based on BIS and ANI monitor.

Use of a Remifentanil-propofol Mixture in Patients Undergoing Breast Cancer Surgery

Use of a Remifentanil-propofol Mixture in Patients With Breast Cancer Undergoing Breast Cancer Surgery: a Prospective Pilot Study

measured by non-invasive blood pressure cuff

total consumption of remifentanil during procedure

total consumption of propofol during procedure

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Use of a Remifentanil-propofol Mixture in Patients Undergoing Breast Cancer Surgery	NCT03817359	Anesthetics Remifentanil Propofol	Remifentanil-pr...	18 Years -	Tri-Service General Hospital
Use of a Remifentanil-propofol Mixture in Patients Undergoing Breast Cancer Surgery	NCT03817359	Anesthetics Remifentanil Propofol	Remifentanil-pr...	18 Years -	Tri-Service General Hospital

Spots Global Cancer Trial Database for anesthetics

Every month we try and update this database with for anesthetics cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for anesthetics

Every month we try and update this database with for anesthetics cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for anesthetics cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.