Neoplasms

Symptoms and General Pathology

All Conditions

Musculoskeletal Diseases

Rare Diseases

Cysts

Bone Cysts

Bone Cysts, Aneurysmal

Pathological Conditions, Anatomical

Bone Diseases

Aneurysmal Bone Cysts

The lesion will be treated with curettage then 1 million of bone marrow derived MSC seeded on 5x5 mm2 PLGA scaffold will be engrafted in the cyst of ABC patient.

Bone marrow derived MSC seeded on biodegradable PLGA, supplemented with PL.

MSC-PLGA

Shayma Nazzal, Msc

Abdalla Awidi, MD

Abdalla Awidi

Patients qualified for this study are those diagnosed with ABCs and failed to be treated with other forms of classical therapies. In which, these patients will be engrafted with biodegradable scaffolds seeded with Mesenchymal Stem Cells (MSCs) supplemented with Platelet lysate.

Aneurysmal bone cysts (ABC) are relatively rare, benign, tumor-like, expansile osteolytic lesions of unknown etiology which are predominantly found within the long bones and characterized by frequent idiopathic fractures. Despite the large variety of bone substitutes that have been used to fill these cystic lesions, to date there is no graft material which can be regarded as completely satisfactory, with a recurrence rate that ranges from 5-40% of treated cases. Autologous bone marrow derived mononuclear cells have been used previously to treat ABCs. Poly lactic-co-glycolic acid (PLGA) scaffolds have been used in bone tissue engineering due to their biodegradability and biocompatibility. Human platelet lysate (PL) contains a number of mitogenic growth factors and has been demonstrated to enhance mesenchymal stem cell (MSC) proliferation and expansion rate in vitro. This study is designed to assess the safety and effectiveness of using PLGA scaffolds seeded with autologous bone marrow MSCs and supplemented with osteogenic media and platelet lysate in healing bone lesions of patients suffering from aneurysmal bone cysts. This study will be conducted at the Cell Therapy Center (CTC), Jordan. Four ABC cases will be included. Patients qualified for this study are those diagnosed with ABCs and failed to be treated with other forms of classical therapies; such as allografts or who are not candidate of autografts.

Use of Stem Cells Cultured on a Scaffold for the Treatment of Aneurysmal Bone Cysts (ABC)

Autologous Bone Tissue Constructed On Biodegradable Polymer for the Treatment of Aneurysmal Bone Cysts

The safety of the engraftment will be monitored by assessing any adverse event resulting from the engraftment procedure

Patients will be followed up radiographically to evaluate bone filling at the site of the ABC

Sophia Al-Adwan

Researcher, Msc

Patient aging from 0 to 30 years with diagnosis of aneurysmal bone cyst treated by percutaneous alcolisation or endovascular embolization.

Interventional radiology for aneurysmal bone cyst ( percutaneous alcoholization, vascualr embolisation)

radiology

Catherine CYTEVAL, MD.PhD

This study aims to describe the clinical outcomeand the radiological appearance of aneurysmal bone cyst treated by means of interventional radiology procedures (percutaneous sclerosis and endovascular embolization)

Aneurysmal Bone Cyst Imaging After Interventional Radiology Treatment

Aneurysmal Bone Cyst Imaging After Interventional Radiology Treatment: Clinical and Radiological Outcome

Percentage of peripheral reossification after treatment :

* 0%: no reossification
* \< 25%: low reossification
* Between 25% -50%: Partial reossification
* Between 50-75%: significant reossification
* \> 75%: very significant reossification
* 100%: complete reossifcation

Pain measured with Pain scale ( 0 = no pain , 10 = maximum pain)

Number of patients needs second treatment 3- Fracture ? (yes or no)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Use of Stem Cells Cultured on a Scaffold for the Treatment of Aneurysmal Bone Cysts (ABC)	NCT03066245	Aneurysmal Bone...	MSC-PLGA	4 Years - 28 Years	University of Jordan
Aneurysmal Bone Cyst Imaging After Interventional Radiology Treatment	NCT05075148	Bone Cysts	radiology	0 Years -	University Hospital, Montpellier
Aneurysmal Bone Cyst Imaging After Interventional Radiology Treatment	NCT05075148	Bone Cysts	radiology	0 Years -	University Hospital, Montpellier

Spots Global Cancer Trial Database for aneurysmal bone cyst