Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Breast Neoplasms

Breast Diseases

Skin Diseases

Enrolled participants will be asked to complete a one-time, remote neurocognitive assessment. The neurocognitive assessment will consist of the CogSuite Neurocognitive Battery, an online, remotely deliverable battery of cognitive experimental measures, and a standard battery of remote neuropsychological measures. DNA will be collected via mailed saliva kits to assess Apolipoprotein E (APOE) status.

Sociodemographics, Deficit Accumulation Questionnaires, Remote Cognitive Assessment, Deficit Accumulation Questionnaires,Remote Cognitive Assessment

Assessments

\*Tumor/Treatment Variables (Survivors Only)

Assessment (Survivors Only)

APOE and DNA Isolation

James Root, PhD

Tim Ahles, PhD

The purpose of this study is to look at how differences in cognitive (mental) function develop over time in breast cancer survivors compared to volunteers without a history of cancer (healthy volunteers). Both cancer survivors and healthy volunteers (who are the same age as the cancer survivors) will participate in this study so the researchers can compare the results of neurocognitive testing (which looks at memory, attention, and information processing) on each group of participants.

A Study of Changes in Thinking Related to Aging and Cancer in Breast Cancer Survivors (TRAC)

Cognitive Aging in Older Long-term Breast Cancer Survivors

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.

of remote cancer diagnosis and treatment and potential association with increased/accelerated deficit accumulation in older survivors.The primary outcome is cognitive performance, as measured by CogSuite aggregate intra-individual variability, the average intra-individual variability across the subtests. Cognition will be assessed using the CogSuite battery of five subtests: 1) Attention Network Test; 2) Mental Rotation; 3) Stop Signal Delay; 4) N-back; and 5) Psychomotor Speed measures.

by testing cotinine (an important metabolite of nicotine) in urine samples to examine possible interactions of smoking history with genetic variants, e.g., APOE ε4+, on cognition

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
A Study of Changes in Thinking Related to Aging and Cancer in Breast Cancer Survivors (TRAC)	NCT06334354	Breast Cancer S...	Assessments Assessment (Sur... APOE and DNA Is...	65 Years - 80 Years	Memorial Sloan Kettering Cancer Center
A Study of Changes in Thinking Related to Aging and Cancer in Breast Cancer Survivors (TRAC)	NCT06334354	Breast Cancer S...	Assessments Assessment (Sur... APOE and DNA Is...	65 Years - 80 Years	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for apoe and dna isolation